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Plasma TNF-α and Soluble TNF Receptor Levels after Doxorubicin with or without Co-Administration of Mesna-A Randomized, Cross-Over Clinical Study.
Hayslip J, Dressler EV, Weiss H, Taylor TJ, Chambers M, Noel T, Miriyala S, Keeney JT, Ren X, Sultana R, Vore M, Butterfield DA, St Clair D, Moscow JA. Hayslip J, et al. Among authors: ren x. PLoS One. 2015 Apr 24;10(4):e0124988. doi: 10.1371/journal.pone.0124988. eCollection 2015. PLoS One. 2015. PMID: 25909710 Free PMC article. Clinical Trial.
Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive impairment ("chemobrain").
Keeney JTR, Ren X, Warrier G, Noel T, Powell DK, Brelsfoard JM, Sultana R, Saatman KE, Clair DKS, Butterfield DA. Keeney JTR, et al. Among authors: ren x. Oncotarget. 2018 Jul 13;9(54):30324-30339. doi: 10.18632/oncotarget.25718. eCollection 2018 Jul 13. Oncotarget. 2018. PMID: 30100992 Free PMC article.
The triangle of death of neurons: Oxidative damage, mitochondrial dysfunction, and loss of choline-containing biomolecules in brains of mice treated with doxorubicin. Advanced insights into mechanisms of chemotherapy induced cognitive impairment ("chemobrain") involving TNF-α.
Ren X, Keeney JTR, Miriyala S, Noel T, Powell DK, Chaiswing L, Bondada S, St Clair DK, Butterfield DA. Ren X, et al. Free Radic Biol Med. 2019 Apr;134:1-8. doi: 10.1016/j.freeradbiomed.2018.12.029. Epub 2018 Dec 26. Free Radic Biol Med. 2019. PMID: 30593843 Free PMC article.
Plausible biochemical mechanisms of chemotherapy-induced cognitive impairment ("chemobrain"), a condition that significantly impairs the quality of life of many cancer survivors.
Ren X, Boriero D, Chaiswing L, Bondada S, St Clair DK, Butterfield DA. Ren X, et al. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1088-1097. doi: 10.1016/j.bbadis.2019.02.007. Epub 2019 Feb 10. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 30759363 Free PMC article. Review.
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