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Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.
Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, LeBlanc A, Smith D, Rigby M, Shearman MS, Clarke EE, Zheng H, Van Der Ploeg LH, Ruffolo SC, Thornberry NA, Xanthoudakis S, Zamboni RJ, Roy S, Nicholson DW. Gervais FG, et al. Among authors: roy s. Cell. 1999 Apr 30;97(3):395-406. doi: 10.1016/s0092-8674(00)80748-5. Cell. 1999. PMID: 10319819 Free article.
Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.
Rasper DM, Vaillancourt JP, Hadano S, Houtzager VM, Seiden I, Keen SL, Tawa P, Xanthoudakis S, Nasir J, Martindale D, Koop BF, Peterson EP, Thornberry NA, Huang J, MacPherson DP, Black SC, Hornung F, Lenardo MJ, Hayden MR, Roy S, Nicholson DW. Rasper DM, et al. Among authors: roy s. Cell Death Differ. 1998 Apr;5(4):271-88. doi: 10.1038/sj.cdd.4400370. Cell Death Differ. 1998. PMID: 10200473
Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics.
Méthot N, Huang J, Coulombe N, Vaillancourt JP, Rasper D, Tam J, Han Y, Colucci J, Zamboni R, Xanthoudakis S, Toulmond S, Nicholson DW, Roy S. Méthot N, et al. Among authors: roy s. J Exp Med. 2004 Jan 19;199(2):199-207. doi: 10.1084/jem.20031791. Epub 2004 Jan 12. J Exp Med. 2004. PMID: 14718517 Free PMC article.
Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease.
Toulmond S, Tang K, Bureau Y, Ashdown H, Degen S, O'Donnell R, Tam J, Han Y, Colucci J, Giroux A, Zhu Y, Boucher M, Pikounis B, Xanthoudakis S, Roy S, Rigby M, Zamboni R, Robertson GS, Ng GY, Nicholson DW, Flückiger JP. Toulmond S, et al. Among authors: roy s. Br J Pharmacol. 2004 Feb;141(4):689-97. doi: 10.1038/sj.bjp.0705662. Epub 2004 Jan 26. Br J Pharmacol. 2004. PMID: 14744804 Free PMC article.
Solid phase synthesis of selective caspase-3 peptide inhibitors.
Grimm EL, Roy B, Aspiotis R, Bayly CI, Nicholson DW, Rasper DM, Renaud J, Roy S, Tam J, Tawa P, Vaillancourt JP, Xanthoudakis S, Zamboni RJ. Grimm EL, et al. Among authors: roy b, roy s. Bioorg Med Chem. 2004 Mar 1;12(5):845-51. doi: 10.1016/j.bmc.2004.01.007. Bioorg Med Chem. 2004. PMID: 14980595
Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.
Han Y, Giroux A, Colucci J, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt J, Rasper DM, Tam J, Tawa P, Nicholson DW, Zamboni RJ. Han Y, et al. Among authors: roy s. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1173-80. doi: 10.1016/j.bmcl.2004.12.006. Bioorg Med Chem Lett. 2005. PMID: 15686936
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