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Discontinuation of treatment with IFN-beta leads to exacerbation of experimental autoimmune encephalomyelitis in Lewis rats. Rapid reversal of the antiproliferative activity of IFN-beta and excessive expansion of autoreactive T cells as disease promoting mechanisms.
van der Meide PH, de Labie MC, Ruuls SR, Groenestein RJ, Botman CA, Olsson T, Dijkstra CD. van der Meide PH, et al. Among authors: ruuls sr. J Neuroimmunol. 1998 Apr 1;84(1):14-23. doi: 10.1016/s0165-5728(97)00207-5. J Neuroimmunol. 1998. PMID: 9600704
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