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An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schäfer A, Dinnon KH 3rd, Stevens LJ, Chappell JD, Lu X, Hughes TM, George AS, Hill CS, Montgomery SA, Brown AJ, Bluemling GR, Natchus MG, Saindane M, Kolykhalov AA, Painter G, Harcourt J, Tamin A, Thornburg NJ, Swanstrom R, Denison MR, Baric RS. Sheahan TP, et al. Among authors: saindane m. Sci Transl Med. 2020 Apr 29;12(541):eabb5883. doi: 10.1126/scitranslmed.abb5883. Epub 2020 Apr 6. Sci Transl Med. 2020. PMID: 32253226 Free PMC article.
Asymmetric synthesis of host-directed inhibitors of myxoviruses.
Moore TW, Sana K, Yan D, Thepchatri P, Ndungu JM, Saindane MT, Lockwood MA, Natchus MG, Liotta DC, Plemper RK, Snyder JP, Sun A. Moore TW, et al. Among authors: saindane mt. Beilstein J Org Chem. 2013;9:197-203. doi: 10.3762/bjoc.9.23. Epub 2013 Jan 30. Beilstein J Org Chem. 2013. PMID: 23400228 Free PMC article.
Discovery of tetrahydroisoquinoline-based CXCR4 antagonists.
Truax VM, Zhao H, Katzman BM, Prosser AR, Alcaraz AA, Saindane MT, Howard RB, Culver D, Arrendale RF, Gruddanti PR, Evers TJ, Natchus MG, Snyder JP, Liotta DC, Wilson LJ. Truax VM, et al. Among authors: saindane mt. ACS Med Chem Lett. 2013 Sep 5;4(11):1025-30. doi: 10.1021/ml400183q. eCollection 2013 Nov 14. ACS Med Chem Lett. 2013. PMID: 24936240 Free PMC article.
Discovery of a Fluorinated Enigmol Analog with Enhanced in Vivo Pharmacokinetic and Anti-Tumor Properties.
Miller EJ, Mays SG, Baillie MT, Howard RB, Culver DG, Saindane M, Pruett ST, Holt JJ, Menaldino DS, Evers TJ, Reddy GP, Arrendale RF, Natchus MG, Petros JA, Liotta DC. Miller EJ, et al. Among authors: saindane m. ACS Med Chem Lett. 2016 Mar 21;7(5):537-42. doi: 10.1021/acsmedchemlett.6b00113. eCollection 2016 May 12. ACS Med Chem Lett. 2016. PMID: 27190606 Free PMC article.
Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance.
Agostini ML, Pruijssers AJ, Chappell JD, Gribble J, Lu X, Andres EL, Bluemling GR, Lockwood MA, Sheahan TP, Sims AC, Natchus MG, Saindane M, Kolykhalov AA, Painter GR, Baric RS, Denison MR. Agostini ML, et al. Among authors: saindane m. J Virol. 2019 Nov 26;93(24):e01348-19. doi: 10.1128/JVI.01348-19. Print 2019 Dec 15. J Virol. 2019. PMID: 31578288 Free PMC article.
ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens.
Squires KE, Mayers DL, Bluemling GR, Kolykhalov AA, Guthrie DB, Reddy P, Mitchell DG, Saindane MT, Sticher ZM, Edpuganti V, De La Rosa A. Squires KE, et al. Among authors: saindane mt. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00836-20. doi: 10.1128/AAC.00836-20. Print 2020 Aug 20. Antimicrob Agents Chemother. 2020. PMID: 32540975 Free PMC article.
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