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ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a "Toggle Switch" of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells.
Almairac F, Turchi L, Sakakini N, Debruyne DN, Elkeurti S, Gjernes E, Polo B, Bianchini L, Fontaine D, Paquis P, Chneiweiss H, Junier MP, Verrando P, Burel-Vandenbos F, Virolle T. Almairac F, et al. Among authors: sakakini n. Cancer Res. 2020 Aug 15;80(16):3236-3250. doi: 10.1158/0008-5472.CAN-19-0855. Epub 2020 May 4. Cancer Res. 2020. PMID: 32366479
A Positive Feed-forward Loop Associating EGR1 and PDGFA Promotes Proliferation and Self-renewal in Glioblastoma Stem Cells.
Sakakini N, Turchi L, Bergon A, Holota H, Rekima S, Lopez F, Paquis P, Almairac F, Fontaine D, Baeza-Kallee N, Van Obberghen-Schilling E, Junier MP, Chneiweiss H, Figarella-Branger D, Burel-Vandenbos F, Imbert J, Virolle T. Sakakini N, et al. J Biol Chem. 2016 May 13;291(20):10684-99. doi: 10.1074/jbc.M116.720698. Epub 2016 Mar 21. J Biol Chem. 2016. PMID: 27002148 Free PMC article.
CELF2 Sustains a Proliferating/OLIG2+ Glioblastoma Cell Phenotype via the Epigenetic Repression of SOX3.
Turchi L, Sakakini N, Saviane G, Polo B, Saurty-Seerunghen MS, Gabut M, Gouillou CA, Guerlais V, Pasquier C, Vignais ML, Almairac F, Chneiweiss H, Junier MP, Burel-Vandenbos F, Virolle T. Turchi L, et al. Among authors: sakakini n. Cancers (Basel). 2023 Oct 18;15(20):5038. doi: 10.3390/cancers15205038. Cancers (Basel). 2023. PMID: 37894405 Free PMC article.
Simultaneous hyper- and hypomethylation at imprinted loci in a subset of patients with GNAS epimutations underlies a complex and different mechanism of multilocus methylation defect in pseudohypoparathyroidism type 1b.
Maupetit-Méhouas S, Azzi S, Steunou V, Sakakini N, Silve C, Reynes C, Perez de Nanclares G, Keren B, Chantot S, Barlier A, Linglart A, Netchine I. Maupetit-Méhouas S, et al. Among authors: sakakini n. Hum Mutat. 2013 Aug;34(8):1172-80. doi: 10.1002/humu.22352. Epub 2013 May 28. Hum Mutat. 2013. PMID: 23649963
A guide to epigenetics in leukaemia stem cells.
Agrawal-Singh S, Bagri J, Sakakini N, Huntly BJP. Agrawal-Singh S, et al. Among authors: sakakini n. Mol Oncol. 2023 Dec;17(12):2493-2506. doi: 10.1002/1878-0261.13544. Epub 2023 Nov 2. Mol Oncol. 2023. PMID: 37872885 Free PMC article. Review.
Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay.
Juban G, Sakakini N, Chagraoui H, Cruz Hernandez D, Cheng Q, Soady K, Stoilova B, Garnett C, Waithe D, Otto G, Doondeea J, Usukhbayar B, Karkoulia E, Alexiou M, Strouboulis J, Morrissey E, Roberts I, Porcher C, Vyas P. Juban G, et al. Among authors: sakakini n. Haematologica. 2021 Apr 1;106(4):1106-1119. doi: 10.3324/haematol.2019.244541. Haematologica. 2021. PMID: 32527952 Free PMC article.