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Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway.
Nethe M, Anthony EC, Fernandez-Borja M, Dee R, Geerts D, Hensbergen PJ, Deelder AM, Schmidt G, Hordijk PL. Nethe M, et al. Among authors: schmidt g. J Cell Sci. 2010 Jun 1;123(Pt 11):1948-58. doi: 10.1242/jcs.062919. Epub 2010 May 11. J Cell Sci. 2010. PMID: 20460433
IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation.
Oberoi TK, Dogan T, Hocking JC, Scholz RP, Mooz J, Anderson CL, Karreman C, Meyer zu Heringdorf D, Schmidt G, Ruonala M, Namikawa K, Harms GS, Carpy A, Macek B, Köster RW, Rajalingam K. Oberoi TK, et al. Among authors: schmidt g. EMBO J. 2012 Jan 4;31(1):14-28. doi: 10.1038/emboj.2011.423. Epub 2011 Nov 25. EMBO J. 2012. PMID: 22117219 Free PMC article.
Inhibition of Rho A activity causes pemphigus skin blistering.
Waschke J, Spindler V, Bruggeman P, Zillikens D, Schmidt G, Drenckhahn D. Waschke J, et al. Among authors: schmidt g. J Cell Biol. 2006 Dec 4;175(5):721-7. doi: 10.1083/jcb.200605125. Epub 2006 Nov 27. J Cell Biol. 2006. PMID: 17130286 Free PMC article.
RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes.
Jackson B, Peyrollier K, Pedersen E, Basse A, Karlsson R, Wang Z, Lefever T, Ochsenbein AM, Schmidt G, Aktories K, Stanley A, Quondamatteo F, Ladwein M, Rottner K, van Hengel J, Brakebusch C. Jackson B, et al. Among authors: schmidt g. Mol Biol Cell. 2011 Mar 1;22(5):593-605. doi: 10.1091/mbc.E09-10-0859. Epub 2011 Jan 5. Mol Biol Cell. 2011. PMID: 21209320 Free PMC article.
2,621 results