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Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.
Coxon FP, Helfrich MH, Larijani B, Muzylak M, Dunford JE, Marshall D, McKinnon AD, Nesbitt SA, Horton MA, Seabra MC, Ebetino FH, Rogers MJ. Coxon FP, et al. Among authors: seabra mc. J Biol Chem. 2001 Dec 21;276(51):48213-22. doi: 10.1074/jbc.M106473200. Epub 2001 Oct 1. J Biol Chem. 2001. PMID: 11581260 Free article.
Rab GTPases, intracellular traffic and disease.
Seabra MC, Mules EH, Hume AN. Seabra MC, et al. Trends Mol Med. 2002 Jan;8(1):23-30. doi: 10.1016/s1471-4914(01)02227-4. Trends Mol Med. 2002. PMID: 11796263 Review.
Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid.
McKenna CE, Kashemirov BA, Błazewska KM, Mallard-Favier I, Stewart CA, Rojas J, Lundy MW, Ebetino FH, Baron RA, Dunford JE, Kirsten ML, Seabra MC, Bala JL, Marma MS, Rogers MJ, Coxon FP. McKenna CE, et al. Among authors: seabra mc. J Med Chem. 2010 May 13;53(9):3454-64. doi: 10.1021/jm900232u. J Med Chem. 2010. PMID: 20394422
A role for Rab27b in NF-E2-dependent pathways of platelet formation.
Tiwari S, Italiano JE Jr, Barral DC, Mules EH, Novak EK, Swank RT, Seabra MC, Shivdasani RA. Tiwari S, et al. Among authors: seabra mc. Blood. 2003 Dec 1;102(12):3970-9. doi: 10.1182/blood-2003-03-0977. Epub 2003 Aug 7. Blood. 2003. PMID: 12907454 Free article.
181 results