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ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification.
Jordan R, Goff A, Frimm A, Corrado ML, Hensley LE, Byrd CM, Mucker E, Shamblin J, Bolken TC, Wlazlowski C, Johnson W, Chapman J, Twenhafel N, Tyavanagimatt S, Amantana A, Chinsangaram J, Hruby DE, Huggins J. Jordan R, et al. Among authors: shamblin j. Antimicrob Agents Chemother. 2009 May;53(5):1817-22. doi: 10.1128/AAC.01596-08. Epub 2009 Feb 17. Antimicrob Agents Chemother. 2009. PMID: 19223621 Free PMC article. Clinical Trial.
Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox.
Earl PL, Americo JL, Wyatt LS, Eller LA, Whitbeck JC, Cohen GH, Eisenberg RJ, Hartmann CJ, Jackson DL, Kulesh DA, Martinez MJ, Miller DM, Mucker EM, Shamblin JD, Zwiers SH, Huggins JW, Jahrling PB, Moss B. Earl PL, et al. Among authors: shamblin jd. Nature. 2004 Mar 11;428(6979):182-5. doi: 10.1038/nature02331. Nature. 2004. PMID: 15014500
Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246.
Huggins J, Goff A, Hensley L, Mucker E, Shamblin J, Wlazlowski C, Johnson W, Chapman J, Larsen T, Twenhafel N, Karem K, Damon IK, Byrd CM, Bolken TC, Jordan R, Hruby D. Huggins J, et al. Among authors: shamblin j. Antimicrob Agents Chemother. 2009 Jun;53(6):2620-5. doi: 10.1128/AAC.00021-09. Epub 2009 Apr 6. Antimicrob Agents Chemother. 2009. PMID: 19349521 Free PMC article.
The pathogenesis of Rift Valley fever virus in the mouse model.
Smith DR, Steele KE, Shamblin J, Honko A, Johnson J, Reed C, Kennedy M, Chapman JL, Hensley LE. Smith DR, et al. Among authors: shamblin j. Virology. 2010 Nov 25;407(2):256-67. doi: 10.1016/j.virol.2010.08.016. Epub 2010 Sep 17. Virology. 2010. PMID: 20850165 Free article.
Development of a novel nonhuman primate model for Rift Valley fever.
Smith DR, Bird BH, Lewis B, Johnston SC, McCarthy S, Keeney A, Botto M, Donnelly G, Shamblin J, Albariño CG, Nichol ST, Hensley LE. Smith DR, et al. Among authors: shamblin j. J Virol. 2012 Feb;86(4):2109-20. doi: 10.1128/JVI.06190-11. Epub 2011 Dec 7. J Virol. 2012. PMID: 22156530 Free PMC article.
Ultrastructural study of Rift Valley fever virus in the mouse model.
Reed C, Steele KE, Honko A, Shamblin J, Hensley LE, Smith DR. Reed C, et al. Among authors: shamblin j. Virology. 2012 Sep 15-30;431(1-2):58-70. doi: 10.1016/j.virol.2012.05.012. Epub 2012 Jun 9. Virology. 2012. PMID: 22687428 Free article.
Aerosol exposure to Rift Valley fever virus causes earlier and more severe neuropathology in the murine model, which has important implications for therapeutic development.
Reed C, Lin K, Wilhelmsen C, Friedrich B, Nalca A, Keeney A, Donnelly G, Shamblin J, Hensley LE, Olinger G, Smith DR. Reed C, et al. Among authors: shamblin j. PLoS Negl Trop Dis. 2013 Apr 4;7(4):e2156. doi: 10.1371/journal.pntd.0002156. Print 2013. PLoS Negl Trop Dis. 2013. PMID: 23593523 Free PMC article.
Efficacy of tecovirimat (ST-246) in nonhuman primates infected with variola virus (Smallpox).
Mucker EM, Goff AJ, Shamblin JD, Grosenbach DW, Damon IK, Mehal JM, Holman RC, Carroll D, Gallardo N, Olson VA, Clemmons CJ, Hudson P, Hruby DE. Mucker EM, et al. Among authors: shamblin jd. Antimicrob Agents Chemother. 2013 Dec;57(12):6246-53. doi: 10.1128/AAC.00977-13. Epub 2013 Oct 7. Antimicrob Agents Chemother. 2013. PMID: 24100494 Free PMC article.
78 results