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An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schäfer A, Dinnon KH 3rd, Stevens LJ, Chappell JD, Lu X, Hughes TM, George AS, Hill CS, Montgomery SA, Brown AJ, Bluemling GR, Natchus MG, Saindane M, Kolykhalov AA, Painter G, Harcourt J, Tamin A, Thornburg NJ, Swanstrom R, Denison MR, Baric RS. Sheahan TP, et al. Sci Transl Med. 2020 Apr 29;12(541):eabb5883. doi: 10.1126/scitranslmed.abb5883. Epub 2020 Apr 6. Sci Transl Med. 2020. PMID: 32253226 Free PMC article.
SARS coronavirus vaccine development.
Baric RS, Sheahan T, Deming D, Donaldson E, Yount B, Sims AC, Roberts RS, Frieman M, Rockx B. Baric RS, et al. Adv Exp Med Biol. 2006;581:553-60. doi: 10.1007/978-0-387-33012-9_101. Adv Exp Med Biol. 2006. PMID: 17037597 Free PMC article. No abstract available.
A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice.
Roberts A, Deming D, Paddock CD, Cheng A, Yount B, Vogel L, Herman BD, Sheahan T, Heise M, Genrich GL, Zaki SR, Baric R, Subbarao K. Roberts A, et al. PLoS Pathog. 2007 Jan;3(1):e5. doi: 10.1371/journal.ppat.0030005. PLoS Pathog. 2007. PMID: 17222058 Free PMC article. Clinical Trial.
Animal models and vaccines for SARS-CoV infection.
Roberts A, Lamirande EW, Vogel L, Jackson JP, Paddock CD, Guarner J, Zaki SR, Sheahan T, Baric R, Subbarao K. Roberts A, et al. Virus Res. 2008 Apr;133(1):20-32. doi: 10.1016/j.virusres.2007.03.025. Epub 2007 May 11. Virus Res. 2008. PMID: 17499378 Free PMC article.
98 results