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A direct-acting antiviral drug abrogates viremia in Zika virus-infected rhesus macaques.
Lim SY, Osuna CE, Best K, Taylor R, Chen E, Yoon G, Kublin JL, Schalk D, Schultz-Darken N, Capuano S, Safronetz D, Luo M, MacLennan S, Mathis A, Babu YS, Sheridan WP, Perelson AS, Whitney JB. Lim SY, et al. Among authors: sheridan wp. Sci Transl Med. 2020 Jun 10;12(547):eaau9135. doi: 10.1126/scitranslmed.aau9135. Sci Transl Med. 2020. PMID: 32522808 Free PMC article.
Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model.
Julander JG, Siddharthan V, Evans J, Taylor R, Tolbert K, Apuli C, Stewart J, Collins P, Gebre M, Neilson S, Van Wettere A, Lee YM, Sheridan WP, Morrey JD, Babu YS. Julander JG, et al. Among authors: sheridan wp. Antiviral Res. 2017 Jan;137:14-22. doi: 10.1016/j.antiviral.2016.11.003. Epub 2016 Nov 10. Antiviral Res. 2017. PMID: 27838352 Free PMC article.
BCX4430, a novel nucleoside analog, effectively treats yellow fever in a Hamster model.
Julander JG, Bantia S, Taubenheim BR, Minning DM, Kotian P, Morrey JD, Smee DF, Sheridan WP, Babu YS. Julander JG, et al. Among authors: sheridan wp. Antimicrob Agents Chemother. 2014 Nov;58(11):6607-14. doi: 10.1128/AAC.03368-14. Epub 2014 Aug 25. Antimicrob Agents Chemother. 2014. PMID: 25155605 Free PMC article.
BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease.
Taylor R, Kotian P, Warren T, Panchal R, Bavari S, Julander J, Dobo S, Rose A, El-Kattan Y, Taubenheim B, Babu Y, Sheridan WP. Taylor R, et al. Among authors: sheridan wp. J Infect Public Health. 2016 May-Jun;9(3):220-6. doi: 10.1016/j.jiph.2016.04.002. Epub 2016 Apr 16. J Infect Public Health. 2016. PMID: 27095300 Free PMC article. Review.
Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.
Warren TK, Wells J, Panchal RG, Stuthman KS, Garza NL, Van Tongeren SA, Dong L, Retterer CJ, Eaton BP, Pegoraro G, Honnold S, Bantia S, Kotian P, Chen X, Taubenheim BR, Welch LS, Minning DM, Babu YS, Sheridan WP, Bavari S. Warren TK, et al. Among authors: sheridan wp. Nature. 2014 Apr 17;508(7496):402-5. doi: 10.1038/nature13027. Epub 2014 Mar 2. Nature. 2014. PMID: 24590073 Free PMC article.
90 results