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Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques.
Hessell AJ, Jaworski JP, Epson E, Matsuda K, Pandey S, Kahl C, Reed J, Sutton WF, Hammond KB, Cheever TA, Barnette PT, Legasse AW, Planer S, Stanton JJ, Pegu A, Chen X, Wang K, Siess D, Burke D, Park BS, Axthelm MK, Lewis A, Hirsch VM, Graham BS, Mascola JR, Sacha JB, Haigwood NL. Hessell AJ, et al. Among authors: siess d. Nat Med. 2016 Apr;22(4):362-8. doi: 10.1038/nm.4063. Epub 2016 Mar 21. Nat Med. 2016. PMID: 26998834 Free PMC article.
Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity.
Shapiro MB, Cheever T, Malherbe DC, Pandey S, Reed J, Yang ES, Wang K, Pegu A, Chen X, Siess D, Burke D, Henderson H, Lewinsohn R, Fischer M, Stanton JJ, Axthelm MK, Kahl C, Park B, Lewis AD, Sacha JB, Mascola JR, Hessell AJ, Haigwood NL. Shapiro MB, et al. Among authors: siess d. Nat Commun. 2020 Jan 7;11(1):70. doi: 10.1038/s41467-019-13972-y. Nat Commun. 2020. PMID: 31911610 Free PMC article.
Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission.
Chang XL, Webb GM, Wu HL, Greene JM, Abdulhaqq S, Bateman KB, Reed JS, Pessoa C, Weber WC, Maier N, Chew GM, Gilbride RM, Gao L, Agnor R, Giobbi T, Torgerson J, Siess D, Burnett N, Fischer M, Shiel O, Moats C, Patterson B, Dhody K, Kelly S, Pourhassan N, Magnani DM, Smedley J, Bimber BN, Haigwood NL, Hansen SG, Brown TR, Ndhlovu LC, Sacha JB. Chang XL, et al. Among authors: siess d. Nat Commun. 2021 Jun 7;12(1):3343. doi: 10.1038/s41467-021-23697-6. Nat Commun. 2021. PMID: 34099693 Free PMC article.
Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge.
Hansen SG, Vieville C, Whizin N, Coyne-Johnson L, Siess DC, Drummond DD, Legasse AW, Axthelm MK, Oswald K, Trubey CM, Piatak M Jr, Lifson JD, Nelson JA, Jarvis MA, Picker LJ. Hansen SG, et al. Among authors: siess dc. Nat Med. 2009 Mar;15(3):293-9. doi: 10.1038/nm.1935. Epub 2009 Feb 15. Nat Med. 2009. PMID: 19219024 Free PMC article.
Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection.
Picker LJ, Hagen SI, Lum R, Reed-Inderbitzin EF, Daly LM, Sylwester AW, Walker JM, Siess DC, Piatak M Jr, Wang C, Allison DB, Maino VC, Lifson JD, Kodama T, Axthelm MK. Picker LJ, et al. Among authors: siess dc. J Exp Med. 2004 Nov 15;200(10):1299-314. doi: 10.1084/jem.20041049. J Exp Med. 2004. PMID: 15545355 Free PMC article.
Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus.
Hansen SG, Powers CJ, Richards R, Ventura AB, Ford JC, Siess D, Axthelm MK, Nelson JA, Jarvis MA, Picker LJ, Früh K. Hansen SG, et al. Among authors: siess d. Science. 2010 Apr 2;328(5974):102-6. doi: 10.1126/science.1185350. Science. 2010. PMID: 20360110 Free PMC article.
Suppression of human and simian immunodeficiency virus replication with the CCR5-specific antibody Leronlimab in two species.
Chang XL, Reed JS, Webb GM, Wu HL, Le J, Bateman KB, Greene JM, Pessoa C, Waytashek C, Weber WC, Hwang J, Fischer M, Moats C, Shiel O, Bochart RM, Crank H, Siess D, Giobbi T, Torgerson J, Agnor R, Gao L, Dhody K, Lalezari JP, Bandar IS, Carnate AM, Pang AS, Corley MJ, Kelly S, Pourhassan N, Smedley J, Bimber BN, Hansen SG, Ndhlovu LC, Sacha JB. Chang XL, et al. Among authors: siess d. PLoS Pathog. 2022 Mar 31;18(3):e1010396. doi: 10.1371/journal.ppat.1010396. eCollection 2022 Mar. PLoS Pathog. 2022. PMID: 35358290 Free PMC article.
Cytomegalovirus pp65 limits dissemination but is dispensable for persistence.
Malouli D, Hansen SG, Nakayasu ES, Marshall EE, Hughes CM, Ventura AB, Gilbride RM, Lewis MS, Xu G, Kreklywich C, Whizin N, Fischer M, Legasse AW, Viswanathan K, Siess D, Camp DG 2nd, Axthelm MK, Kahl C, DeFilippis VR, Smith RD, Streblow DN, Picker LJ, Früh K. Malouli D, et al. Among authors: siess d. J Clin Invest. 2014 May;124(5):1928-44. doi: 10.1172/JCI67420. Epub 2014 Apr 1. J Clin Invest. 2014. PMID: 24691437 Free PMC article.
17 results