Spelsberg TC - Search Results

1

Endoxifen's molecular mechanisms of action are concentration dependent and different than that of other anti-estrogens.

Hawse JR, Subramaniam M, Cicek M, Wu X, Gingery A, Grygo SB, Sun Z, Pitel KS, Lingle WL, Goetz MP, Ingle JN, Spelsberg TC. Hawse JR, et al. Among authors: spelsberg tc. PLoS One. 2013;8(1):e54613. doi: 10.1371/journal.pone.0054613. Epub 2013 Jan 28. PLoS One. 2013. PMID: 23382923 Free PMC article.

2

The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells.

Wu X, Hawse JR, Subramaniam M, Goetz MP, Ingle JN, Spelsberg TC. Wu X, et al. Among authors: spelsberg tc. Cancer Res. 2009 Mar 1;69(5):1722-7. doi: 10.1158/0008-5472.CAN-08-3933. Epub 2009 Feb 24. Cancer Res. 2009. PMID: 19244106

3

Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen.

Wu X, Subramaniam M, Grygo SB, Sun Z, Negron V, Lingle WL, Goetz MP, Ingle JN, Spelsberg TC, Hawse JR. Wu X, et al. Among authors: spelsberg tc. Breast Cancer Res. 2011 Mar 10;13(2):R27. doi: 10.1186/bcr2844. Breast Cancer Res. 2011. PMID: 21392396 Free PMC article.

4

TIEG1/KLF10 modulates Runx2 expression and activity in osteoblasts.

Hawse JR, Cicek M, Grygo SB, Bruinsma ES, Rajamannan NM, van Wijnen AJ, Lian JB, Stein GS, Oursler MJ, Subramaniam M, Spelsberg TC. Hawse JR, et al. Among authors: spelsberg tc. PLoS One. 2011 Apr 29;6(4):e19429. doi: 10.1371/journal.pone.0019429. PLoS One. 2011. PMID: 21559363 Free PMC article.

5

Development, characterization, and applications of a novel estrogen receptor beta monoclonal antibody.

Wu X, Subramaniam M, Negron V, Cicek M, Reynolds C, Lingle WL, Goetz MP, Ingle JN, Spelsberg TC, Hawse JR. Wu X, et al. Among authors: spelsberg tc. J Cell Biochem. 2012 Feb;113(2):711-23. doi: 10.1002/jcb.23443. J Cell Biochem. 2012. PMID: 22095450 Free PMC article.

6

TGFβ inducible early gene-1 plays an important role in mediating estrogen signaling in the skeleton.

Hawse JR, Pitel KS, Cicek M, Philbrick KA, Gingery A, Peters KD, Syed FA, Ingle JN, Suman VJ, Iwaniec UT, Turner RT, Spelsberg TC, Subramaniam M. Hawse JR, et al. Among authors: spelsberg tc. J Bone Miner Res. 2014;29(5):1206-16. doi: 10.1002/jbmr.2142. J Bone Miner Res. 2014. PMID: 24190163 Free PMC article.

7

The effects of a novel hormonal breast cancer therapy, endoxifen, on the mouse skeleton.

Gingery A, Subramaniam M, Pitel KS, Reese JM, Cicek M, Lindenmaier LB, Ingle JN, Goetz MP, Turner RT, Iwaniec UT, Spelsberg TC, Hawse JR. Gingery A, et al. Among authors: spelsberg tc. PLoS One. 2014 May 22;9(5):e98219. doi: 10.1371/journal.pone.0098219. eCollection 2014. PLoS One. 2014. PMID: 24853369 Free PMC article.

8

ERβ1: characterization, prognosis, and evaluation of treatment strategies in ERα-positive and -negative breast cancer.

Reese JM, Suman VJ, Subramaniam M, Wu X, Negron V, Gingery A, Pitel KS, Shah SS, Cunliffe HE, McCullough AE, Pockaj BA, Couch FJ, Olson JE, Reynolds C, Lingle WL, Spelsberg TC, Goetz MP, Ingle JN, Hawse JR. Reese JM, et al. Among authors: spelsberg tc. BMC Cancer. 2014 Oct 7;14:749. doi: 10.1186/1471-2407-14-749. BMC Cancer. 2014. PMID: 25288324 Free PMC article.

9

Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue.

Reinholz MM, An MW, Johnsen SA, Subramaniam M, Suman VJ, Ingle JN, Roche PC, Spelsberg TC. Reinholz MM, et al. Among authors: spelsberg tc. Breast Cancer Res Treat. 2004 Jul;86(1):75-88. doi: 10.1023/B:BREA.0000032926.74216.7d. Breast Cancer Res Treat. 2004. PMID: 15218362

10

Estrogen receptor alpha and beta heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2OS osteosarcoma cells.

Monroe DG, Secreto FJ, Subramaniam M, Getz BJ, Khosla S, Spelsberg TC. Monroe DG, et al. Among authors: spelsberg tc. Mol Endocrinol. 2005 Jun;19(6):1555-68. doi: 10.1210/me.2004-0381. Epub 2005 Mar 31. Mol Endocrinol. 2005. PMID: 15802376

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