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Factor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising "Hot-Spot" Lysine Residues.
van den Biggelaar M, Madsen JJ, Faber JH, Zuurveld MG, van der Zwaan C, Olsen OH, Stennicke HR, Mertens K, Meijer AB. van den Biggelaar M, et al. Among authors: stennicke hr. J Biol Chem. 2015 Jul 3;290(27):16463-76. doi: 10.1074/jbc.M115.650911. Epub 2015 Apr 21. J Biol Chem. 2015. PMID: 25903134 Free PMC article.
A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models.
Stennicke HR, Kjalke M, Karpf DM, Balling KW, Johansen PB, Elm T, Øvlisen K, Möller F, Holmberg HL, Gudme CN, Persson E, Hilden I, Pelzer H, Rahbek-Nielsen H, Jespersgaard C, Bogsnes A, Pedersen AA, Kristensen AK, Peschke B, Kappers W, Rode F, Thim L, Tranholm M, Ezban M, Olsen EH, Bjørn SE. Stennicke HR, et al. Blood. 2013 Mar 14;121(11):2108-16. doi: 10.1182/blood-2012-01-407494. Epub 2013 Jan 18. Blood. 2013. PMID: 23335368 Free PMC article.
An induced proximity model for caspase-8 activation.
Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM. Muzio M, et al. Among authors: stennicke hr. J Biol Chem. 1998 Jan 30;273(5):2926-30. doi: 10.1074/jbc.273.5.2926. J Biol Chem. 1998. PMID: 9446604 Free article.
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