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An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models.
Schepens B, van Schie L, Nerinckx W, Roose K, Van Breedam W, Fijalkowska D, Devos S, Weyts W, De Cae S, Vanmarcke S, Lonigro C, Eeckhaut H, Van Herpe D, Borloo J, Oliveira AF, Catani JPP, Creytens S, De Vlieger D, Michielsen G, Marchan JCZ, Moschonas GD, Rossey I, Sedeyn K, Van Hecke A, Zhang X, Langendries L, Jacobs S, Ter Horst S, Seldeslachts L, Liesenborghs L, Boudewijns R, Thibaut HJ, Dallmeier K, Velde GV, Weynand B, Beer J, Schnepf D, Ohnemus A, Remory I, Foo CS, Abdelnabi R, Maes P, Kaptein SJF, Rocha-Pereira J, Jochmans D, Delang L, Peelman F, Staeheli P, Schwemmle M, Devoogdt N, Tersago D, Germani M, Heads J, Henry A, Popplewell A, Ellis M, Brady K, Turner A, Dombrecht B, Stortelers C, Neyts J, Callewaert N, Saelens X. Schepens B, et al. Among authors: stortelers c. Sci Transl Med. 2021 Nov 24;13(621):eabi7826. doi: 10.1126/scitranslmed.abi7826. Epub 2021 Nov 24. Sci Transl Med. 2021. PMID: 34609205 Free PMC article.
Nanobodies®: new ammunition to battle viruses.
Vanlandschoot P, Stortelers C, Beirnaert E, Ibañez LI, Schepens B, Depla E, Saelens X. Vanlandschoot P, et al. Among authors: stortelers c. Antiviral Res. 2011 Dec;92(3):389-407. doi: 10.1016/j.antiviral.2011.09.002. Epub 2011 Sep 10. Antiviral Res. 2011. PMID: 21939690 Review.
Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data.
Deschaght P, Vintém AP, Logghe M, Conde M, Felix D, Mensink R, Gonçalves J, Audiens J, Bruynooghe Y, Figueiredo R, Ramos D, Tanghe R, Teixeira D, Van de Ven L, Stortelers C, Dombrecht B. Deschaght P, et al. Among authors: stortelers c. Front Immunol. 2017 Apr 10;8:420. doi: 10.3389/fimmu.2017.00420. eCollection 2017. Front Immunol. 2017. PMID: 28443097 Free PMC article.
Protective effect of different anti-rabies virus VHH constructs against rabies disease in mice.
Terryn S, Francart A, Lamoral S, Hultberg A, Rommelaere H, Wittelsberger A, Callewaert F, Stohr T, Meerschaert K, Ottevaere I, Stortelers C, Vanlandschoot P, Kalai M, Van Gucht S. Terryn S, et al. Among authors: stortelers c. PLoS One. 2014 Oct 27;9(10):e109367. doi: 10.1371/journal.pone.0109367. eCollection 2014. PLoS One. 2014. PMID: 25347556 Free PMC article.
CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells.
Schütze K, Petry K, Hambach J, Schuster N, Fumey W, Schriewer L, Röckendorf J, Menzel S, Albrecht B, Haag F, Stortelers C, Bannas P, Koch-Nolte F. Schütze K, et al. Among authors: stortelers c. Front Immunol. 2018 Nov 19;9:2553. doi: 10.3389/fimmu.2018.02553. eCollection 2018. Front Immunol. 2018. PMID: 30524421 Free PMC article.
Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection.
Detalle L, Stohr T, Palomo C, Piedra PA, Gilbert BE, Mas V, Millar A, Power UF, Stortelers C, Allosery K, Melero JA, Depla E. Detalle L, et al. Among authors: stortelers c. Antimicrob Agents Chemother. 2015 Oct 5;60(1):6-13. doi: 10.1128/AAC.01802-15. Print 2016 Jan. Antimicrob Agents Chemother. 2015. PMID: 26438495 Free PMC article.
Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation.
Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop JH, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Koch-Nolte F. Danquah W, et al. Among authors: stortelers c. Sci Transl Med. 2016 Nov 23;8(366):366ra162. doi: 10.1126/scitranslmed.aaf8463. Sci Transl Med. 2016. PMID: 27881823
Trivalency of a Nanobody Specific for the Human Respiratory Syncytial Virus Fusion Glycoprotein Drastically Enhances Virus Neutralization and Impacts Escape Mutant Selection.
Palomo C, Mas V, Detalle L, Depla E, Cano O, Vázquez M, Stortelers C, Melero JA. Palomo C, et al. Among authors: stortelers c. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6498-6509. doi: 10.1128/AAC.00842-16. Print 2016 Nov. Antimicrob Agents Chemother. 2016. PMID: 27550346 Free PMC article.
Anti-TTR Nanobodies Allow the Identification of TTR Neuritogenic Epitope Associated with TTR-Megalin Neurotrophic Activities.
Gomes JR, Sárkány Z, Teixeira A, Nogueira R, Cabrito I, Soares H, Wittelsberger A, Stortelers C, Macedo-Ribeiro S, Vanlandschoot P, Saraiva MJ. Gomes JR, et al. Among authors: stortelers c. ACS Chem Neurosci. 2019 Jan 16;10(1):704-715. doi: 10.1021/acschemneuro.8b00502. Epub 2018 Oct 23. ACS Chem Neurosci. 2019. PMID: 30346709
28 results