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SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.
Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH 2nd, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi LE, Barbry P, Leslie A, Kiem HP, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J; HCA Lung Biological Network. Electronic address: lung-network@humancellatlas.org; HCA Lung Biological Network. Ziegler CGK, et al. Among authors: tkachev v. Cell. 2020 May 28;181(5):1016-1035.e19. doi: 10.1016/j.cell.2020.04.035. Epub 2020 Apr 27. Cell. 2020. PMID: 32413319 Free PMC article.
Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells.
Furlan SN, Watkins B, Tkachev V, Cooley S, Panoskaltsis-Mortari A, Betz K, Brown M, Hunt DJ, Schell JB, Zeleski K, Yu A, Giver CR, Waller EK, Miller JS, Blazar BR, Kean LS. Furlan SN, et al. Among authors: tkachev v. Blood. 2016 Nov 24;128(21):2568-2579. doi: 10.1182/blood-2016-07-726547. Epub 2016 Oct 6. Blood. 2016. PMID: 27758873 Free PMC article.
Preclinical Testing of Antihuman CD28 Fab' Antibody in a Novel Nonhuman Primate Small Animal Rodent Model of Xenogenic Graft-Versus-Host Disease.
Hippen KL, Watkins B, Tkachev V, Lemire AM, Lehnen C, Riddle MJ, Singh K, Panoskaltsis-Mortari A, Vanhove B, Tolar J, Kean LS, Blazar BR. Hippen KL, et al. Among authors: tkachev v. Transplantation. 2016 Dec;100(12):2630-2639. doi: 10.1097/TP.0000000000001465. Transplantation. 2016. PMID: 27861291 Free PMC article.
Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant.
Tkachev V, Furlan SN, Watkins B, Hunt DJ, Zheng HB, Panoskaltsis-Mortari A, Betz K, Brown M, Schell JB, Zeleski K, Yu A, Kirby I, Cooley S, Miller JS, Blazar BR, Casson D, Bland-Ward P, Kean LS. Tkachev V, et al. Sci Transl Med. 2017 Sep 20;9(408):eaan3085. doi: 10.1126/scitranslmed.aan3085. Sci Transl Med. 2017. PMID: 28931653 Free PMC article.
Chimeric Antigen Receptor T Cell-Mediated Neurotoxicity in Nonhuman Primates.
Taraseviciute A, Tkachev V, Ponce R, Turtle CJ, Snyder JM, Liggitt HD, Myerson D, Gonzalez-Cuyar L, Baldessari A, English C, Yu A, Zheng H, Furlan SN, Hunt DJ, Hoglund V, Finney O, Brakke H, Blazar BR, Berger C, Riddell SR, Gardner R, Kean LS, Jensen MC. Taraseviciute A, et al. Among authors: tkachev v. Cancer Discov. 2018 Jun;8(6):750-763. doi: 10.1158/2159-8290.CD-17-1368. Epub 2018 Mar 21. Cancer Discov. 2018. PMID: 29563103 Free PMC article.
CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates.
Watkins BK, Tkachev V, Furlan SN, Hunt DJ, Betz K, Yu A, Brown M, Poirier N, Zheng HB, Taraseviciute A, Colonna L, Mary C, Blancho G, Soulillou JP, Panoskaltsis-Mortari A, Sharma P, Garcia A, Strobert E, Hamby K, Garrett A, Deane T, Blazar BR, Vanhove B, Kean LS. Watkins BK, et al. Among authors: tkachev v. J Clin Invest. 2018 Aug 31;128(9):3991-4007. doi: 10.1172/JCI98793. Epub 2018 Aug 13. J Clin Invest. 2018. PMID: 30102255 Free PMC article.
Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation.
Colonna L, Peterson CW, Schell JB, Carlson JM, Tkachev V, Brown M, Yu A, Reddy S, Obenza WM, Nelson V, Polacino PS, Mack H, Hu SL, Zeleski K, Hoffman M, Olvera J, Furlan SN, Zheng H, Taraseviciute A, Hunt DJ, Betz K, Lane JF, Vogel K, Hotchkiss CE, Moats C, Baldessari A, Murnane RD, English C, Astley CA, Wangari S, Agricola B, Ahrens J, Iwayama N, May A, Stensland L, Huang MW, Jerome KR, Kiem HP, Kean LS. Colonna L, et al. Among authors: tkachev v. Nat Commun. 2018 Oct 25;9(1):4438. doi: 10.1038/s41467-018-06736-7. Nat Commun. 2018. PMID: 30361514 Free PMC article.
Current Concepts and Advances in Graft-Versus-Host Disease Immunology.
Hill GR, Betts BC, Tkachev V, Kean LS, Blazar BR. Hill GR, et al. Among authors: tkachev v. Annu Rev Immunol. 2021 Apr 26;39:19-49. doi: 10.1146/annurev-immunol-102119-073227. Epub 2021 Jan 11. Annu Rev Immunol. 2021. PMID: 33428454 Free PMC article.
Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease.
Tkachev V, Kaminski J, Potter EL, Furlan SN, Yu A, Hunt DJ, McGuckin C, Zheng H, Colonna L, Gerdemann U, Carlson J, Hoffman M, Olvera J, English C, Baldessari A, Panoskaltsis-Mortari A, Watkins B, Qayed M, Suessmuth Y, Betz K, Bratrude B, Langston A, Horan JT, Ordovas-Montanes J, Shalek AK, Blazar BR, Roederer M, Kean LS. Tkachev V, et al. Sci Transl Med. 2021 Jan 13;13(576):eabc0227. doi: 10.1126/scitranslmed.abc0227. Sci Transl Med. 2021. PMID: 33441422 Free PMC article.
182 results