Toonen JA - Search Results

1

Smithson LJ, Anastasaki C, Chen R, Toonen JA, Williams SB, Gutmann DH. Smithson LJ, et al. Among authors: toonen ja. Semin Cell Dev Biol. 2016 Oct;58:118-26. doi: 10.1016/j.semcdb.2016.06.002. Epub 2016 Jun 3. Semin Cell Dev Biol. 2016. PMID: 27269372 Free PMC article. Review.

2

The impact of coexisting genetic mutations on murine optic glioma biology.

Kaul A, Toonen JA, Gianino SM, Gutmann DH. Kaul A, et al. Among authors: toonen ja. Neuro Oncol. 2015 May;17(5):670-7. doi: 10.1093/neuonc/nou287. Epub 2014 Sep 21. Neuro Oncol. 2015. PMID: 25246427 Free PMC article.

3

Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth.

Kaul A, Toonen JA, Cimino PJ, Gianino SM, Gutmann DH. Kaul A, et al. Among authors: toonen ja. Neuro Oncol. 2015 Jun;17(6):843-53. doi: 10.1093/neuonc/nou329. Epub 2014 Dec 21. Neuro Oncol. 2015. PMID: 25534823 Free PMC article.

4

NF1 germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1.

Toonen JA, Anastasaki C, Smithson LJ, Gianino SM, Li K, Kesterson RA, Gutmann DH. Toonen JA, et al. Hum Mol Genet. 2016 May 1;25(9):1703-13. doi: 10.1093/hmg/ddw039. Epub 2016 Feb 16. Hum Mol Genet. 2016. PMID: 26908603 Free PMC article.

5

Estrogen activation of microglia underlies the sexually dimorphic differences in Nf1 optic glioma-induced retinal pathology.

Toonen JA, Solga AC, Ma Y, Gutmann DH. Toonen JA, et al. J Exp Med. 2017 Jan;214(1):17-25. doi: 10.1084/jem.20160447. Epub 2016 Dec 6. J Exp Med. 2017. PMID: 27923908 Free PMC article.

6

Defining the temporal course of murine neurofibromatosis-1 optic gliomagenesis reveals a therapeutic window to attenuate retinal dysfunction.

Toonen JA, Ma Y, Gutmann DH. Toonen JA, et al. Neuro Oncol. 2017 Jun 1;19(6):808-819. doi: 10.1093/neuonc/now267. Neuro Oncol. 2017. PMID: 28039362 Free PMC article.

7

NF1 mutation drives neuronal activity-dependent initiation of optic glioma.

Pan Y, Hysinger JD, Barron T, Schindler NF, Cobb O, Guo X, Yalçın B, Anastasaki C, Mulinyawe SB, Ponnuswami A, Scheaffer S, Ma Y, Chang KC, Xia X, Toonen JA, Lennon JJ, Gibson EM, Huguenard JR, Liau LM, Goldberg JL, Monje M, Gutmann DH. Pan Y, et al. Among authors: toonen ja. Nature. 2021 Jun;594(7862):277-282. doi: 10.1038/s41586-021-03580-6. Epub 2021 May 26. Nature. 2021. PMID: 34040258 Free PMC article.

8

Increased Tissue Stiffness in Tumors from Mice with Neurofibromatosis-1 Optic Glioma.

Walter C, Crawford L, Lai M, Toonen JA, Pan Y, Sakiyama-Elbert S, Gutmann DH, Pathak A. Walter C, et al. Among authors: toonen ja. Biophys J. 2017 Apr 25;112(8):1535-1538. doi: 10.1016/j.bpj.2017.03.017. Biophys J. 2017. PMID: 28445745 Free PMC article.

9

The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation.

Solga AC, Toonen JA, Pan Y, Cimino PJ, Ma Y, Castillon GA, Gianino SM, Ellisman MH, Lee DY, Gutmann DH. Solga AC, et al. Among authors: toonen ja. Oncotarget. 2017 Jul 18;8(29):47206-47215. doi: 10.18632/oncotarget.17589. Oncotarget. 2017. PMID: 28525381 Free PMC article.

10

Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature.

Pan Y, Bush EC, Toonen JA, Ma Y, Solga AC, Sims PA, Gutmann DH. Pan Y, et al. Among authors: toonen ja. Oncotarget. 2017 Apr 18;8(32):52474-52487. doi: 10.18632/oncotarget.17193. eCollection 2017 Aug 8. Oncotarget. 2017. PMID: 28881745 Free PMC article.

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