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Broad-spectrum coronavirus antiviral drug discovery.
Totura AL, Bavari S. Totura AL, et al. Expert Opin Drug Discov. 2019 Apr;14(4):397-412. doi: 10.1080/17460441.2019.1581171. Epub 2019 Mar 8. Expert Opin Drug Discov. 2019. PMID: 30849247 Free PMC article. Review.
A comprehensive collection of systems biology data characterizing the host response to viral infection.
Aevermann BD, Pickett BE, Kumar S, Klem EB, Agnihothram S, Askovich PS, Bankhead A 3rd, Bolles M, Carter V, Chang J, Clauss TR, Dash P, Diercks AH, Eisfeld AJ, Ellis A, Fan S, Ferris MT, Gralinski LE, Green RR, Gritsenko MA, Hatta M, Heegel RA, Jacobs JM, Jeng S, Josset L, Kaiser SM, Kelly S, Law GL, Li C, Li J, Long C, Luna ML, Matzke M, McDermott J, Menachery V, Metz TO, Mitchell H, Monroe ME, Navarro G, Neumann G, Podyminogin RL, Purvine SO, Rosenberger CM, Sanders CJ, Schepmoes AA, Shukla AK, Sims A, Sova P, Tam VC, Tchitchek N, Thomas PG, Tilton SC, Totura A, Wang J, Webb-Robertson BJ, Wen J, Weiss JM, Yang F, Yount B, Zhang Q, McWeeney S, Smith RD, Waters KM, Kawaoka Y, Baric R, Aderem A, Katze MG, Scheuermann RH. Aevermann BD, et al. Among authors: totura a. Sci Data. 2014 Oct 14;1:140033. doi: 10.1038/sdata.2014.33. eCollection 2014. Sci Data. 2014. PMID: 25977790 Free PMC article.
A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge.
Bolles M, Deming D, Long K, Agnihothram S, Whitmore A, Ferris M, Funkhouser W, Gralinski L, Totura A, Heise M, Baric RS. Bolles M, et al. Among authors: totura a. J Virol. 2011 Dec;85(23):12201-15. doi: 10.1128/JVI.06048-11. Epub 2011 Sep 21. J Virol. 2011. PMID: 21937658 Free PMC article.
Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice.
Tchitchek N, Eisfeld AJ, Tisoncik-Go J, Josset L, Gralinski LE, Bécavin C, Tilton SC, Webb-Robertson BJ, Ferris MT, Totura AL, Li C, Neumann G, Metz TO, Smith RD, Waters KM, Baric R, Kawaoka Y, Katze MG. Tchitchek N, et al. Among authors: totura al. BMC Syst Biol. 2013 Jul 29;7:69. doi: 10.1186/1752-0509-7-69. BMC Syst Biol. 2013. PMID: 23895213 Free PMC article.
Persistence of Severe Acute Respiratory Syndrome Coronavirus 2 in Aerosol Suspensions.
Fears AC, Klimstra WB, Duprex P, Hartman A, Weaver SC, Plante KS, Mirchandani D, Plante JA, Aguilar PV, Fernández D, Nalca A, Totura A, Dyer D, Kearney B, Lackemeyer M, Bohannon JK, Johnson R, Garry RF, Reed DS, Roy CJ. Fears AC, et al. Among authors: totura a. Emerg Infect Dis. 2020 Sep;26(9):2168-71. doi: 10.3201/eid2609.201806. Epub 2020 Jun 22. Emerg Infect Dis. 2020. PMID: 32568661 Free PMC article.
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