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An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models.
Schepens B, van Schie L, Nerinckx W, Roose K, Van Breedam W, Fijalkowska D, Devos S, Weyts W, De Cae S, Vanmarcke S, Lonigro C, Eeckhaut H, Van Herpe D, Borloo J, Oliveira AF, Catani JPP, Creytens S, De Vlieger D, Michielsen G, Marchan JCZ, Moschonas GD, Rossey I, Sedeyn K, Van Hecke A, Zhang X, Langendries L, Jacobs S, Ter Horst S, Seldeslachts L, Liesenborghs L, Boudewijns R, Thibaut HJ, Dallmeier K, Velde GV, Weynand B, Beer J, Schnepf D, Ohnemus A, Remory I, Foo CS, Abdelnabi R, Maes P, Kaptein SJF, Rocha-Pereira J, Jochmans D, Delang L, Peelman F, Staeheli P, Schwemmle M, Devoogdt N, Tersago D, Germani M, Heads J, Henry A, Popplewell A, Ellis M, Brady K, Turner A, Dombrecht B, Stortelers C, Neyts J, Callewaert N, Saelens X. Schepens B, et al. Among authors: van breedam w. Sci Transl Med. 2021 Nov 24;13(621):eabi7826. doi: 10.1126/scitranslmed.abi7826. Epub 2021 Nov 24. Sci Transl Med. 2021. PMID: 34609205 Free PMC article.
Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.
Wrapp D, De Vlieger D, Corbett KS, Torres GM, Wang N, Van Breedam W, Roose K, van Schie L; VIB-CMB COVID-19 Response Team; Hoffmann M, Pöhlmann S, Graham BS, Callewaert N, Schepens B, Saelens X, McLellan JS. Wrapp D, et al. Among authors: van breedam w. Cell. 2020 May 28;181(5):1004-1015.e15. doi: 10.1016/j.cell.2020.04.031. Epub 2020 May 5. Cell. 2020. PMID: 32375025 Free PMC article.
Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.
Wrapp D, De Vlieger D, Corbett KS, Torres GM, Wang N, Van Breedam W, Roose K, van Schie L; VIB-CMB COVID-19 Response Team; Hoffmann M, Pöhlmann S, Graham BS, Callewaert N, Schepens B, Saelens X, McLellan JS. Wrapp D, et al. Among authors: van breedam w. Cell. 2020 Jun 11;181(6):1436-1441. doi: 10.1016/j.cell.2020.05.047. Cell. 2020. PMID: 32531248 Free PMC article. No abstract available.
GlycoVHH: optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery.
van Schie L, Van Breedam W, Roels C, Schepens B, Frank M, Mehdipour AR, Laukens B, Nerinckx W, Santens F, Devos S, Rossey I, Thooft K, Vanmarcke S, Van Hecke A, Saelens X, Callewaert N. van Schie L, et al. Among authors: van breedam w. MAbs. 2023 Jan-Dec;15(1):2210709. doi: 10.1080/19420862.2023.2210709. MAbs. 2023. PMID: 37211816 Free PMC article.
Comparison of the efficacy of autogenous inactivated Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccines with that of commercial vaccines against homologous and heterologous challenges.
Geldhof MF, Vanhee M, Van Breedam W, Van Doorsselaere J, Karniychuk UU, Nauwynck HJ. Geldhof MF, et al. Among authors: van breedam w. BMC Vet Res. 2012 Oct 3;8:182. doi: 10.1186/1746-6148-8-182. BMC Vet Res. 2012. PMID: 23031319 Free PMC article. Clinical Trial.
Porcine reproductive and respiratory syndrome virus (PRRSV)-specific mAbs: supporting diagnostics and providing new insights into the antigenic properties of the virus.
Van Breedam W, Costers S, Vanhee M, Gagnon CA, Rodríguez-Gómez IM, Geldhof M, Verbeeck M, Van Doorsselaere J, Karniychuk U, Nauwynck HJ. Van Breedam W, et al. Among authors: van doorsselaere j. Vet Immunol Immunopathol. 2011 Jun 15;141(3-4):246-57. doi: 10.1016/j.vetimm.2011.03.008. Epub 2011 Mar 12. Vet Immunol Immunopathol. 2011. PMID: 21470695
23 results