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TLR2 ligand-synthetic long peptide conjugates effectively stimulate tumor-draining lymph node T cells of cervical cancer patients.
Zom GG, Welters MJ, Loof NM, Goedemans R, Lougheed S, Valentijn RR, Zandvliet ML, Meeuwenoord NJ, Melief CJ, de Gruijl TD, Van der Marel GA, Filippov DV, Ossendorp F, Van der Burg SH. Zom GG, et al. Among authors: van der marel ga, van der burg sh. Oncotarget. 2016 Oct 11;7(41):67087-67100. doi: 10.18632/oncotarget.11512. Oncotarget. 2016. PMID: 27564262 Free PMC article.
Novel TLR2-binding adjuvant induces enhanced T cell responses and tumor eradication.
Zom GG, Willems MMJHP, Khan S, van der Sluis TC, Kleinovink JW, Camps MGM, van der Marel GA, Filippov DV, Melief CJM, Ossendorp F. Zom GG, et al. Among authors: van der marel ga, van der sluis tc. J Immunother Cancer. 2018 Dec 12;6(1):146. doi: 10.1186/s40425-018-0455-2. J Immunother Cancer. 2018. PMID: 30541631 Free PMC article.
Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells.
Khan S, Bijker MS, Weterings JJ, Tanke HJ, Adema GJ, van Hall T, Drijfhout JW, Melief CJ, Overkleeft HS, van der Marel GA, Filippov DV, van der Burg SH, Ossendorp F. Khan S, et al. Among authors: van der marel ga, van hall t, van der burg sh. J Biol Chem. 2007 Jul 20;282(29):21145-59. doi: 10.1074/jbc.M701705200. Epub 2007 Apr 26. J Biol Chem. 2007. PMID: 17462991 Free article.
N-tetradecylcarbamyl lipopeptides as novel agonists for Toll-like receptor 2.
Willems MM, Zom GG, Khan S, Meeuwenoord N, Melief CJ, van der Stelt M, Overkleeft HS, Codée JD, van der Marel GA, Ossendorp F, Filippov DV. Willems MM, et al. Among authors: van der stelt m, van der marel ga. J Med Chem. 2014 Aug 14;57(15):6873-8. doi: 10.1021/jm500722p. Epub 2014 Jul 23. J Med Chem. 2014. PMID: 25019313
Lipophilic Muramyl Dipeptide-Antigen Conjugates as Immunostimulating Agents.
Willems MM, Zom GG, Meeuwenoord N, Khan S, Ossendorp F, Overkleeft HS, van der Marel GA, Filippov DV, Codée JD. Willems MM, et al. Among authors: van der marel ga. ChemMedChem. 2016 Jan 19;11(2):190-8. doi: 10.1002/cmdc.201500196. Epub 2015 Jun 9. ChemMedChem. 2016. PMID: 26059481
Peptides conjugated to 2-alkoxy-8-oxo-adenine as potential synthetic vaccines triggering TLR7.
Gential GPP, Hogervorst TP, Tondini E, van de Graaff MJ, Overkleeft HS, Codée JDC, van der Marel GA, Ossendorp F, Filippov DV. Gential GPP, et al. Among authors: van der marel ga, van de graaff mj. Bioorg Med Chem Lett. 2019 Jun 1;29(11):1340-1344. doi: 10.1016/j.bmcl.2019.03.048. Epub 2019 Mar 30. Bioorg Med Chem Lett. 2019. PMID: 30952595 Free article.
510 results