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The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex.
Verweij MC, Koppers-Lalic D, Loch S, Klauschies F, de la Salle H, Quinten E, Lehner PJ, Mulder A, Knittler MR, Tampé R, Koch J, Ressing ME, Wiertz EJ. Verweij MC, et al. J Immunol. 2008 Oct 1;181(7):4894-907. doi: 10.4049/jimmunol.181.7.4894. J Immunol. 2008. PMID: 18802093
Herpesviruses and immunity: the art of evasion.
Griffin BD, Verweij MC, Wiertz EJ. Griffin BD, et al. Among authors: verweij mc. Vet Microbiol. 2010 Jun 16;143(1):89-100. doi: 10.1016/j.vetmic.2010.02.017. Epub 2010 Feb 25. Vet Microbiol. 2010. PMID: 20303681 Review.
Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP.
Koppers-Lalic D, Verweij MC, Lipińska AD, Wang Y, Quinten E, Reits EA, Koch J, Loch S, Marcondes Rezende M, Daus F, Bieńkowska-Szewczyk K, Osterrieder N, Mettenleiter TC, Heemskerk MH, Tampé R, Neefjes JJ, Chowdhury SI, Ressing ME, Rijsewijk FA, Wiertz EJ. Koppers-Lalic D, et al. Among authors: verweij mc. PLoS Pathog. 2008 May 30;4(5):e1000080. doi: 10.1371/journal.ppat.1000080. PLoS Pathog. 2008. PMID: 18516302 Free PMC article.
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