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Engineered CD47 protects T cells for enhanced antitumour immunity.
Yamada-Hunter SA, Theruvath J, McIntosh BJ, Freitas KA, Lin F, Radosevich MT, Leruste A, Dhingra S, Martinez-Velez N, Xu P, Huang J, Delaidelli A, Desai MH, Good Z, Polak R, May A, Labanieh L, Bjelajac J, Murty T, Ehlinger Z, Mount CW, Chen Y, Heitzeneder S, Marjon KD, Banuelos A, Khan O, Wasserman SL, Spiegel JY, Fernandez-Pol S, Kuo CJ, Sorensen PH, Monje M, Majzner RG, Weissman IL, Sahaf B, Sotillo E, Cochran JR, Mackall CL. Yamada-Hunter SA, et al. Among authors: weissman il. Nature. 2024 May 15. doi: 10.1038/s41586-024-07443-8. Online ahead of print. Nature. 2024. PMID: 38750365
P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by Borrelia burgdorferi.
Tal MC, Hansen PS, Ogasawara HA, Feng Q, Volk RF, Lee B, Casebeer SE, Blacker GS, Shoham M, Galloway SD, Sapiro AL, Hayes B, Dulgeroff LBT, Raveh T, Pothineni VR, Potula HS, Rajadas J, Bastounis EE, Chou S, Robinson WH, Coburn J, Weissman IL, Zaro BW. Tal MC, et al. Among authors: weissman il. bioRxiv [Preprint]. 2024 Apr 30:2024.04.29.591704. doi: 10.1101/2024.04.29.591704. bioRxiv. 2024. PMID: 38746193 Free PMC article. Preprint.
Interstitial macrophages are a focus of viral takeover and inflammation in COVID-19 initiation in human lung.
Wu TT, Travaglini KJ, Rustagi A, Xu D, Zhang Y, Andronov L, Jang S, Gillich A, Dehghannasiri R, Martínez-Colón GJ, Beck A, Liu DD, Wilk AJ, Morri M, Trope WL, Bierman R, Weissman IL, Shrager JB, Quake SR, Kuo CS, Salzman J, Moerner WE, Kim PS, Blish CA, Krasnow MA. Wu TT, et al. Among authors: weissman il. J Exp Med. 2024 Jun 3;221(6):e20232192. doi: 10.1084/jem.20232192. Epub 2024 Apr 10. J Exp Med. 2024. PMID: 38597954 Free PMC article.
Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells.
Fowler JL, Zheng SL, Nguyen A, Chen A, Xiong X, Chai T, Chen JY, Karigane D, Banuelos AM, Niizuma K, Kayamori K, Nishimura T, Cromer MK, Gonzalez-Perez D, Mason C, Liu DD, Yilmaz L, Miquerol L, Porteus MH, Luca VC, Majeti R, Nakauchi H, Red-Horse K, Weissman IL, Ang LT, Loh KM. Fowler JL, et al. Among authors: weissman il. Dev Cell. 2024 May 6;59(9):1110-1131.e22. doi: 10.1016/j.devcel.2024.03.003. Epub 2024 Apr 2. Dev Cell. 2024. PMID: 38569552 Free PMC article.
SCGB1D2 inhibits growth of Borrelia burgdorferi and affects susceptibility to Lyme disease.
Strausz S, Abner E, Blacker G, Galloway S, Hansen P, Feng Q, Lee BT, Jones SE, Haapaniemi H, Raak S, Nahass GR, Sanders E; FinnGen; Estonian Genome Centre; Estonian Biobank Research Team; Soodla P, Võsa U, Esko T, Sinnott-Armstrong N, Weissman IL, Daly M, Aivelo T, Tal MC, Ollila HM. Strausz S, et al. Among authors: weissman il. Nat Commun. 2024 Mar 19;15(1):2041. doi: 10.1038/s41467-024-45983-9. Nat Commun. 2024. PMID: 38503741 Free PMC article.
UCHL1 is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas.
Liu S, Chai T, Garcia-Marques F, Yin Q, Hsu EC, Shen M, Shaw Toland AM, Bermudez A, Hartono AB, Massey CF, Lee CS, Zheng L, Baron M, Denning CJ, Aslan M, Nguyen HM, Nolley R, Zoubeidi A, Das M, Kunder CA, Howitt BE, Soh HT, Weissman IL, Liss MA, Chin AI, Brooks JD, Corey E, Pitteri SJ, Huang J, Stoyanova T. Liu S, et al. Among authors: weissman il. Cell Rep Med. 2024 Feb 20;5(2):101381. doi: 10.1016/j.xcrm.2023.101381. Epub 2024 Jan 19. Cell Rep Med. 2024. PMID: 38244540 Free PMC article.
SIRPα controls CD47-dependent platelet clearance in mice and humans.
Shoham M, Yiu YY, Hansen PS, Subramaniam A, Broberg M, Gars E, Raveh T, FinnGen, Weissman IL, Sinnott-Armstrong N, Krishnan A, Ollila HM, Tal MC. Shoham M, et al. Among authors: weissman il. bioRxiv [Preprint]. 2023 Dec 10:2023.12.09.570874. doi: 10.1101/2023.12.09.570874. bioRxiv. 2023. PMID: 38106070 Free PMC article. Preprint.
958 results