Williams D - Search Results

1

Population pharmacokinetics of eltrombopag in healthy subjects and patients with chronic idiopathic thrombocytopenic purpura.

Gibiansky E, Zhang J, Williams D, Wang Z, Ouellet D. Gibiansky E, et al. Among authors: williams d. J Clin Pharmacol. 2011 Jun;51(6):842-56. doi: 10.1177/0091270010375427. Epub 2010 Jul 27. J Clin Pharmacol. 2011. PMID: 20663993 Clinical Trial.

2

Population PK/PD modeling of eltrombopag in subjects with advanced solid tumors with chemotherapy-induced thrombocytopenia.

Hayes S, Mudd PN Jr, Ouellet D, Johnson BM, Williams D, Gibiansky E. Hayes S, et al. Among authors: williams d. Cancer Chemother Pharmacol. 2013 Jun;71(6):1507-20. doi: 10.1007/s00280-013-2150-9. Epub 2013 Apr 6. Cancer Chemother Pharmacol. 2013. PMID: 23564375

3

Eltrombopag does not affect cardiac repolarization: results from a definitive QTc study in healthy subjects.

Matthys G, Park JW, McGuire S, Wire MB, Zhang J, Bowen C, Williams D, Jenkins JM, Peng B. Matthys G, et al. Among authors: williams d. Br J Clin Pharmacol. 2010 Jul;70(1):24-33. doi: 10.1111/j.1365-2125.2010.03646.x. Br J Clin Pharmacol. 2010. PMID: 20642544 Free PMC article. Clinical Trial.

4

Clinical pharmacokinetics, platelet response, and safety of eltrombopag at supratherapeutic doses of up to 200 mg once daily in healthy volunteers.

Matthys G, Park JW, McGuire S, Wire MB, Bowen C, Williams D, Jenkins J, Peng B. Matthys G, et al. Among authors: williams d. J Clin Pharmacol. 2011 Mar;51(3):301-8. doi: 10.1177/0091270010368677. Epub 2010 Apr 23. J Clin Pharmacol. 2011. PMID: 20418510 Clinical Trial.

5

Effect of hepatic or renal impairment on eltrombopag pharmacokinetics.

Bauman JW, Vincent CT, Peng B, Wire MB, Williams DD, Park JW. Bauman JW, et al. Among authors: williams dd. J Clin Pharmacol. 2011 May;51(5):739-50. doi: 10.1177/0091270010372106. Epub 2010 Jul 27. J Clin Pharmacol. 2011. PMID: 20663991 Clinical Trial.

6

Eltrombopag increases plasma rosuvastatin exposure in healthy volunteers.

Allred AJ, Bowen CJ, Park JW, Peng B, Williams DD, Wire MB, Lee E. Allred AJ, et al. Among authors: williams dd. Br J Clin Pharmacol. 2011 Aug;72(2):321-9. doi: 10.1111/j.1365-2125.2011.03972.x. Br J Clin Pharmacol. 2011. PMID: 21434975 Free PMC article. Clinical Trial.

7

Effects of food and antacids on the pharmacokinetics of eltrombopag in healthy adult subjects: two single-dose, open-label, randomized-sequence, crossover studies.

Williams DD, Peng B, Bailey CK, Wire MB, Deng Y, Park JW, Collins DA, Kapsi SG, Jenkins JM. Williams DD, et al. Clin Ther. 2009 Apr;31(4):764-76. doi: 10.1016/j.clinthera.2009.04.010. Clin Ther. 2009. PMID: 19446149 Clinical Trial.

8

Eltrombopag, an oral thrombopoietin receptor agonist, has no impact on the pharmacokinetic profile of probe drugs for cytochrome P450 isoenzymes CYP3A4, CYP1A2, CYP2C9 and CYP2C19 in healthy men: a cocktail analysis.

Jenkins J, Williams D, Deng Y, Collins DA, Kitchen VS. Jenkins J, et al. Among authors: williams d. Eur J Clin Pharmacol. 2010 Jan;66(1):67-76. doi: 10.1007/s00228-009-0716-6. Epub 2009 Sep 16. Eur J Clin Pharmacol. 2010. PMID: 19756558

9

Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist.

Jenkins JM, Williams D, Deng Y, Uhl J, Kitchen V, Collins D, Erickson-Miller CL. Jenkins JM, et al. Among authors: williams d. Blood. 2007 Jun 1;109(11):4739-41. doi: 10.1182/blood-2006-11-057968. Epub 2007 Feb 27. Blood. 2007. PMID: 17327409 Free article. Clinical Trial.

10

Metabolism and disposition of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist, in healthy human subjects.

Deng Y, Madatian A, Wire MB, Bowen C, Park JW, Williams D, Peng B, Schubert E, Gorycki F, Levy M, Gorycki PD. Deng Y, et al. Among authors: williams d. Drug Metab Dispos. 2011 Sep;39(9):1734-46. doi: 10.1124/dmd.111.040170. Epub 2011 Jun 6. Drug Metab Dispos. 2011. PMID: 21646437 Clinical Trial.

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