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Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.
Wirawan E, Vande Walle L, Kersse K, Cornelis S, Claerhout S, Vanoverberghe I, Roelandt R, De Rycke R, Verspurten J, Declercq W, Agostinis P, Vanden Berghe T, Lippens S, Vandenabeele P. Wirawan E, et al. Cell Death Dis. 2010;1(1):e18. doi: 10.1038/cddis.2009.16. Cell Death Dis. 2010. PMID: 21364619 Free PMC article.
Major cell death pathways at a glance.
Duprez L, Wirawan E, Vanden Berghe T, Vandenabeele P. Duprez L, et al. Among authors: wirawan e. Microbes Infect. 2009 Nov;11(13):1050-62. doi: 10.1016/j.micinf.2009.08.013. Epub 2009 Sep 4. Microbes Infect. 2009. PMID: 19733681 Free article. Review.
Autophagy: for better or for worse.
Wirawan E, Vanden Berghe T, Lippens S, Agostinis P, Vandenabeele P. Wirawan E, et al. Cell Res. 2012 Jan;22(1):43-61. doi: 10.1038/cr.2011.152. Epub 2011 Sep 13. Cell Res. 2012. PMID: 21912435 Free PMC article. Review.
Beclin1: a role in membrane dynamics and beyond.
Wirawan E, Lippens S, Vanden Berghe T, Romagnoli A, Fimia GM, Piacentini M, Vandenabeele P. Wirawan E, et al. Autophagy. 2012 Jan;8(1):6-17. doi: 10.4161/auto.8.1.16645. Epub 2012 Jan 1. Autophagy. 2012. PMID: 22170155 Review.