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CXCL12/CXCR4 pathway is activated by oncogenic JAK2 in a PI3K-dependent manner.
Abdelouahab H, Zhang Y, Wittner M, Oishi S, Fujii N, Besancenot R, Plo I, Ribrag V, Solary E, Vainchenker W, Barosi G, Louache F. Abdelouahab H, et al. Among authors: wittner m. Oncotarget. 2016 Jul 22;8(33):54082-54095. doi: 10.18632/oncotarget.10789. eCollection 2017 Aug 15. Oncotarget. 2016. PMID: 28903325 Free PMC article.
CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model.
Zhang Y, Patel S, Abdelouahab H, Wittner M, Willekens C, Shen S, Betems A, Joulin V, Opolon P, Bawa O, Pasquier F, Ito M, Fujii N, Gonin P, Solary E, Vainchenker W, Coppo P, De Botton S, Louache F. Zhang Y, et al. Among authors: wittner m. Cell Death Dis. 2012 Oct 4;3(10):e396. doi: 10.1038/cddis.2012.137. Cell Death Dis. 2012. PMID: 23034331 Free PMC article.
Dual role of EZH2 in megakaryocyte differentiation.
Mazzi S, Dessen P, Vieira M, Dufour V, Cambot M, El Khoury M, Antony-Debré I, Arkoun B, Basso-Valentina F, BenAbdoulahab S, Edmond V, Rameau P, Petermann R, Wittner M, Cassinat B, Plo I, Debili N, Raslova H, Vainchenker W. Mazzi S, et al. Among authors: wittner m. Blood. 2021 Oct 28;138(17):1603-1614. doi: 10.1182/blood.2019004638. Blood. 2021. PMID: 34115825 Free PMC article.
Lymphoid differentiation of hematopoietic stem cells requires efficient Cxcr4 desensitization.
Freitas C, Wittner M, Nguyen J, Rondeau V, Biajoux V, Aknin ML, Gaudin F, Beaussant-Cohen S, Bertrand Y, Bellanné-Chantelot C, Donadieu J, Bachelerie F, Espéli M, Dalloul A, Louache F, Balabanian K. Freitas C, et al. Among authors: wittner m. J Exp Med. 2017 Jul 3;214(7):2023-2040. doi: 10.1084/jem.20160806. Epub 2017 May 26. J Exp Med. 2017. PMID: 28550161 Free PMC article.
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging.
Ho YH, Del Toro R, Rivera-Torres J, Rak J, Korn C, García-García A, Macías D, González-Gómez C, Del Monte A, Wittner M, Waller AK, Foster HR, López-Otín C, Johnson RS, Nerlov C, Ghevaert C, Vainchenker W, Louache F, Andrés V, Méndez-Ferrer S. Ho YH, et al. Among authors: wittner m. Cell Stem Cell. 2019 Sep 5;25(3):407-418.e6. doi: 10.1016/j.stem.2019.06.007. Epub 2019 Jul 11. Cell Stem Cell. 2019. PMID: 31303548 Free PMC article.
297 results