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Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.
Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI. Koenig PA, et al. Among authors: wuerth jd. Science. 2021 Feb 12;371(6530):eabe6230. doi: 10.1126/science.abe6230. Epub 2021 Jan 12. Science. 2021. PMID: 33436526 Free PMC article.
Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo.
Bertheloot D, Wanderley CW, Schneider AH, Schiffelers LD, Wuerth JD, Tödtmann JM, Maasewerd S, Hawwari I, Duthie F, Rohland C, Ribeiro LS, Jenster LM, Rosero N, Tesfamariam YM, Cunha FQ, Schmidt FI, Franklin BS. Bertheloot D, et al. Among authors: wuerth jd. EMBO Mol Med. 2022 Jun 8;14(6):e15415. doi: 10.15252/emmm.202115415. Epub 2022 Apr 19. EMBO Mol Med. 2022. PMID: 35438238 Free PMC article.
P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection.
Jenster LM, Lange KE, Normann S, vom Hemdt A, Wuerth JD, Schiffelers LDJ, Tesfamariam YM, Gohr FN, Klein L, Kaltheuner IH, Ebner S, Lapp DJ, Mayer J, Moecking J, Ploegh HL, Latz E, Meissner F, Geyer M, Kümmerer BM, Schmidt FI. Jenster LM, et al. Among authors: wuerth jd. J Exp Med. 2023 Jan 2;220(1):e20220837. doi: 10.1084/jem.20220837. Epub 2022 Oct 31. J Exp Med. 2023. PMID: 36315050 Free PMC article.
Ferreting out viral pathogenesis.
Wuerth JD, Weber F. Wuerth JD, et al. Nat Microbiol. 2019 Mar;4(3):384-385. doi: 10.1038/s41564-019-0390-0. Nat Microbiol. 2019. PMID: 30787477 No abstract available.
11 results