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Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19.
D'Agnillo F, Walters KA, Xiao Y, Sheng ZM, Scherler K, Park J, Gygli S, Rosas LA, Sadtler K, Kalish H, Blatti CA 3rd, Zhu R, Gatzke L, Bushell C, Memoli MJ, O'Day SJ, Fischer TD, Hammond TC, Lee RC, Cash JC, Powers ME, O'Keefe GE, Butnor KJ, Rapkiewicz AV, Travis WD, Layne SP, Kash JC, Taubenberger JK. D'Agnillo F, et al. Among authors: xiao y. Sci Transl Med. 2021 Nov 17;13(620):eabj7790. doi: 10.1126/scitranslmed.abj7790. Epub 2021 Nov 17. Sci Transl Med. 2021. PMID: 34648357 Free PMC article.
Treatment with the reactive oxygen species scavenger EUK-207 reduces lung damage and increases survival during 1918 influenza virus infection in mice.
Kash JC, Xiao Y, Davis AS, Walters KA, Chertow DS, Easterbrook JD, Dunfee RL, Sandouk A, Jagger BW, Schwartzman LM, Kuestner RE, Wehr NB, Huffman K, Rosenthal RA, Ozinsky A, Levine RL, Doctrow SR, Taubenberger JK. Kash JC, et al. Among authors: xiao y. Free Radic Biol Med. 2014 Feb;67:235-47. doi: 10.1016/j.freeradbiomed.2013.10.014. Epub 2013 Oct 17. Free Radic Biol Med. 2014. PMID: 24140866 Free PMC article.
Establishment of a Pig Influenza Challenge Model for Evaluation of Monoclonal Antibody Delivery Platforms.
McNee A, Smith TRF, Holzer B, Clark B, Bessell E, Guibinga G, Brown H, Schultheis K, Fisher P, Ramos S, Nunez A, Bernard M, Graham S, Martini V, Chrun T, Xiao Y, Kash JC, Taubenberger JK, Elliott S, Patel A, Beverley P, Rijal P, Weiner DB, Townsend A, Broderick KE, Tchilian E. McNee A, et al. Among authors: xiao y. J Immunol. 2020 Aug 1;205(3):648-660. doi: 10.4049/jimmunol.2000429. Epub 2020 Jun 26. J Immunol. 2020. PMID: 32591390 Free PMC article.
Pre-existing immunity to influenza virus hemagglutinin stalk might drive selection for antibody-escape mutant viruses in a human challenge model.
Park JK, Xiao Y, Ramuta MD, Rosas LA, Fong S, Matthews AM, Freeman AD, Gouzoulis MA, Batchenkova NA, Yang X, Scherler K, Qi L, Reed S, Athota R, Czajkowski L, Han A, Morens DM, Walters KA, Memoli MJ, Kash JC, Taubenberger JK. Park JK, et al. Among authors: xiao y. Nat Med. 2020 Aug;26(8):1240-1246. doi: 10.1038/s41591-020-0937-x. Epub 2020 Jun 29. Nat Med. 2020. PMID: 32601336 Free PMC article.
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