Zhang L - Search Results

1

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors.

Zhang L, Lin D, Sun X, Curth U, Drosten C, Sauerhering L, Becker S, Rox K, Hilgenfeld R. Zhang L, et al. Science. 2020 Apr 24;368(6489):409-412. doi: 10.1126/science.abb3405. Epub 2020 Mar 20. Science. 2020. PMID: 32198291 Free PMC article.

2

Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.

Sun L, Meijer A, Froeyen M, Zhang L, Thibaut HJ, Baggen J, George S, Vernachio J, van Kuppeveld FJ, Leyssen P, Hilgenfeld R, Neyts J, Delang L. Sun L, et al. Among authors: zhang l. Antimicrob Agents Chemother. 2015 Dec;59(12):7782-5. doi: 10.1128/AAC.01375-15. Epub 2015 Sep 14. Antimicrob Agents Chemother. 2015. PMID: 26369972 Free PMC article.

3

Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor.

Lei J, Hansen G, Nitsche C, Klein CD, Zhang L, Hilgenfeld R. Lei J, et al. Among authors: zhang l. Science. 2016 Jul 29;353(6298):503-5. doi: 10.1126/science.aag2419. Epub 2016 Jul 7. Science. 2016. PMID: 27386922

4

Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology.

Nitsche C, Zhang L, Weigel LF, Schilz J, Graf D, Bartenschlager R, Hilgenfeld R, Klein CD. Nitsche C, et al. Among authors: zhang l. J Med Chem. 2017 Jan 12;60(1):511-516. doi: 10.1021/acs.jmedchem.6b01021. Epub 2016 Dec 14. J Med Chem. 2017. PMID: 27966962

5

Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 protease.

Rut W, Zhang L, Kasperkiewicz P, Poreba M, Hilgenfeld R, Drąg M. Rut W, et al. Among authors: zhang l. Antiviral Res. 2017 Mar;139:88-94. doi: 10.1016/j.antiviral.2016.12.018. Epub 2016 Dec 26. Antiviral Res. 2017. PMID: 28034744

6

Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication.

Kouretova J, Hammamy MZ, Epp A, Hardes K, Kallis S, Zhang L, Hilgenfeld R, Bartenschlager R, Steinmetzer T. Kouretova J, et al. Among authors: zhang l. J Enzyme Inhib Med Chem. 2017 Dec;32(1):712-721. doi: 10.1080/14756366.2017.1306521. J Enzyme Inhib Med Chem. 2017. PMID: 28385094 Free PMC article.

7

STD-NMR experiments identify a structural motif with novel second-site activity against West Nile virus NS2B-NS3 protease.

Schöne T, Grimm LL, Sakai N, Zhang L, Hilgenfeld R, Peters T. Schöne T, et al. Among authors: zhang l. Antiviral Res. 2017 Oct;146:174-183. doi: 10.1016/j.antiviral.2017.09.008. Epub 2017 Sep 18. Antiviral Res. 2017. PMID: 28927677

8

The Structure of the Zika Virus Protease, NS2B/NS3^pro.

Hilgenfeld R, Lei J, Zhang L. Hilgenfeld R, et al. Among authors: zhang l. Adv Exp Med Biol. 2018;1062:131-145. doi: 10.1007/978-981-10-8727-1_10. Adv Exp Med Biol. 2018. PMID: 29845530 Review.

9

Profiling of flaviviral NS2B-NS3 protease specificity provides a structural basis for the development of selective chemical tools that differentiate Dengue from Zika and West Nile viruses.

Rut W, Groborz K, Zhang L, Modrzycka S, Poreba M, Hilgenfeld R, Drag M. Rut W, et al. Among authors: zhang l. Antiviral Res. 2020 Mar;175:104731. doi: 10.1016/j.antiviral.2020.104731. Epub 2020 Jan 31. Antiviral Res. 2020. PMID: 32014497

10

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment.

Zhang L, Lin D, Kusov Y, Nian Y, Ma Q, Wang J, von Brunn A, Leyssen P, Lanko K, Neyts J, de Wilde A, Snijder EJ, Liu H, Hilgenfeld R. Zhang L, et al. J Med Chem. 2020 May 14;63(9):4562-4578. doi: 10.1021/acs.jmedchem.9b01828. Epub 2020 Feb 24. J Med Chem. 2020. PMID: 32045235

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