COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity.
McCulloch LJ, Rawling TJ, Sjöholm K, Franck N, Dankel SN, Price EJ, Knight B, Liversedge NH, Mellgren G, Nystrom F, Carlsson LM, Kos K.
McCulloch LJ, et al. Among authors: dankel sn.
Endocrinology. 2015 Jan;156(1):134-46. doi: 10.1210/en.2014-1042.
Endocrinology. 2015.
PMID: 25337653
In both depots, COL6A3 expression appeared to be lowered in obesity, whereas diet- and surgery-induced weight loss increased COL6A3 expression in SCAT. Leptin treatment caused a dose-dependent decrease in COL6A3 expression, although no effect was seen with insulin or gluco …
In both depots, COL6A3 expression appeared to be lowered in obesity, whereas diet- and surgery-induced weight loss increased COL6A3 expressi …