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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1884 1
1889 1
1900 2
1903 1
1916 1
1919 1
1946 1
1958 1
1960 1
1962 1
1963 1
1967 1
1968 1
1969 4
1971 1
1973 2
1975 5
1976 9
1977 6
1978 5
1979 7
1980 10
1981 14
1982 10
1983 13
1984 24
1985 19
1986 17
1987 20
1988 23
1989 41
1990 37
1991 41
1992 50
1993 58
1994 71
1995 83
1996 89
1997 88
1998 107
1999 133
2000 175
2001 168
2002 238
2003 223
2004 269
2005 354
2006 323
2007 434
2008 405
2009 473
2010 554
2011 671
2012 817
2013 924
2014 1186
2015 1302
2016 1483
2017 1626
2018 1803
2019 2163
2020 2776
2021 3216
2022 3405
2023 3717
2024 1790

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27,552 results

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Page 1
Fanzor is a eukaryotic programmable RNA-guided endonuclease.
Saito M, Xu P, Faure G, Maguire S, Kannan S, Altae-Tran H, Vo S, Desimone A, Macrae RK, Zhang F. Saito M, et al. Nature. 2023 Aug;620(7974):660-668. doi: 10.1038/s41586-023-06356-2. Epub 2023 Jun 28. Nature. 2023. PMID: 37380027 Free PMC article.
RNA-guided systems, which use complementarity between a guide RNA and target nucleic acid sequences for recognition of genetic elements, have a central role in biological processes in both prokaryotes and eukaryotes. For example, the prokaryotic CRISPR-Cas systems p …
RNA-guided systems, which use complementarity between a guide RNA and target nucleic acid sequences for recognition of genetic …
Biomaterials for Periodontal Regeneration.
Deng Y, Liang Y, Liu X. Deng Y, et al. Dent Clin North Am. 2022 Oct;66(4):659-672. doi: 10.1016/j.cden.2022.05.011. Epub 2022 Sep 11. Dent Clin North Am. 2022. PMID: 36216452 Free PMC article. Review.
This article summarizes recent progress in periodontal tissue regeneration from a biomaterial perspective. First, various guide tissue regeneration/guide bone regeneration membranes and grafting biomaterials for periodontal tissue regeneration are overviewed. ...
This article summarizes recent progress in periodontal tissue regeneration from a biomaterial perspective. First, various guide tissu …
Enhancement of Rebaudioside M Production by Structure-Guided Engineering of Glycosyltransferase UGT76G1.
Guo B, Deng Z, Meng F, Wang Q, Zhang Y, Yuan Z, Rao Y. Guo B, et al. J Agric Food Chem. 2022 Apr 27;70(16):5088-5094. doi: 10.1021/acs.jafc.2c01209. Epub 2022 Apr 13. J Agric Food Chem. 2022. PMID: 35417157
Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has been considered as a next generation sweetener. However, a low content of Reb M in Stevia rebaudiana Bertoni and low enzymatic activity …
Owing to zero-calorie and advanced organoleptic properties similar to sucrose, the plant-derived rebaudioside M (Reb M) has be …
Laser-guided lightning.
Houard A, Walch P, Produit T, Moreno V, Mahieu B, Sunjerga A, Herkommer C, Mostajabi A, Andral U, André YB, Lozano M, Bizet L, Schroeder MC, Schimmel G, Moret M, Stanley M, Rison WA, Maurice O, Esmiller B, Michel K, Haas W, Metzger T, Rubinstein M, Rachidi F, Cooray V, Mysyrowicz A, Kasparian J, Wolf JP. Houard A, et al. Nat Photonics. 2023;17(3):231-235. doi: 10.1038/s41566-022-01139-z. Epub 2023 Jan 16. Nat Photonics. 2023. PMID: 36909208 Free PMC article.
An experimental campaign was conducted on the Santis mountain in north-eastern Switzerland during the summer of 2021 with a high-repetition-rate terawatt laser. The guiding of an upward negative lightning leader over a distance of 50 m was recorded by two separate h …
An experimental campaign was conducted on the Santis mountain in north-eastern Switzerland during the summer of 2021 with a high-repetition- …
Effect of Natriuretic Peptide-Guided Therapy on Hospitalization or Cardiovascular Mortality in High-Risk Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial.
Felker GM, Anstrom KJ, Adams KF, Ezekowitz JA, Fiuzat M, Houston-Miller N, Januzzi JL Jr, Mark DB, Piña IL, Passmore G, Whellan DJ, Yang H, Cooper LS, Leifer ES, Desvigne-Nickens P, O'Connor CM. Felker GM, et al. JAMA. 2017 Aug 22;318(8):713-720. doi: 10.1001/jama.2017.10565. JAMA. 2017. PMID: 28829876 Free PMC article. Clinical Trial.
DESIGN, SETTINGS, AND PARTICIPANTS: The Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure (GUIDE-IT) study was a randomized multicenter clinical trial conducted between January 16, 2013, and September 20, 2016, at 45 clinical site …
DESIGN, SETTINGS, AND PARTICIPANTS: The Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure (GUI …
The miniature CRISPR-Cas12m effector binds DNA to block transcription.
Wu WY, Mohanraju P, Liao C, Adiego-Pérez B, Creutzburg SCA, Makarova KS, Keessen K, Lindeboom TA, Khan TS, Prinsen S, Joosten R, Yan WX, Migur A, Laffeber C, Scott DA, Lebbink JHG, Koonin EV, Beisel CL, van der Oost J. Wu WY, et al. Mol Cell. 2022 Dec 1;82(23):4487-4502.e7. doi: 10.1016/j.molcel.2022.11.003. Epub 2022 Nov 24. Mol Cell. 2022. PMID: 36427491 Free article.
CRISPR-Cas are prokaryotic adaptive immune systems. Cas nucleases generally use CRISPR-derived RNA guides to specifically bind and cleave DNA or RNA targets. Here, we describe the experimental characterization of a bacterial CRISPR effector protein Cas12m representing subt …
CRISPR-Cas are prokaryotic adaptive immune systems. Cas nucleases generally use CRISPR-derived RNA guides to specifically bind and cl …
Implantoprosthetic Rehabilitation by Computer-guided Implant Surgery (M-Guide): Case report.
Bjelica R, Viskić J, Batinjan G, Filipović Zore I. Bjelica R, et al. Acta Stomatol Croat. 2022 Mar;56(1):89-94. doi: 10.15644/asc56/1/10. Acta Stomatol Croat. 2022. PMID: 35382487 Free PMC article.
Considering the fact of having a narrow area available for implantation, a computer-guided implant therapy using the M-Guide system was selected. The treatment plan was a prosthetic restoration involving the placement of two implants in areas 15 and 24 and th …
Considering the fact of having a narrow area available for implantation, a computer-guided implant therapy using the M-Guid …
Structural basis for the assembly of the type V CRISPR-associated transposon complex.
Schmitz M, Querques I, Oberli S, Chanez C, Jinek M. Schmitz M, et al. Cell. 2022 Dec 22;185(26):4999-5010.e17. doi: 10.1016/j.cell.2022.11.009. Epub 2022 Nov 25. Cell. 2022. PMID: 36435179 Free PMC article.
Here we present a cryo-electron microscopic structure of a target DNA-bound Cas12k-transposon recruitment complex comprised of RNA-guided Cas12k, TniQ, a polymeric TnsC filament and, unexpectedly, the ribosomal protein S15. ...Transposition activity assays corroborate our …
Here we present a cryo-electron microscopic structure of a target DNA-bound Cas12k-transposon recruitment complex comprised of RNA-guided …
Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity.
Tsuchida CA, Zhang S, Doost MS, Zhao Y, Wang J, O'Brien E, Fang H, Li CP, Li D, Hai ZY, Chuck J, Brötzmann J, Vartoumian A, Burstein D, Chen XW, Nogales E, Doudna JA, Liu JG. Tsuchida CA, et al. Mol Cell. 2022 Mar 17;82(6):1199-1209.e6. doi: 10.1016/j.molcel.2022.02.002. Epub 2022 Feb 25. Mol Cell. 2022. PMID: 35219382 Free PMC article.
A compact protein with a size of <1,000 amino acids, the CRISPR-associated protein CasX is a fundamentally distinct RNA-guided nuclease when compared to Cas9 and Cas12a. Although it can induce RNA-guided genome editing in mammalian cells, the activity of CasX is …
A compact protein with a size of <1,000 amino acids, the CRISPR-associated protein CasX is a fundamentally distinct RNA-guided nuc …
MRI-guided endovascular intervention: current methods and future potential.
Kilbride BF, Narsinh KH, Jordan CD, Mueller K, Moore T, Martin AJ, Wilson MW, Hetts SW. Kilbride BF, et al. Expert Rev Med Devices. 2022 Oct;19(10):763-778. doi: 10.1080/17434440.2022.2141110. Expert Rev Med Devices. 2022. PMID: 36373162 Free PMC article. Review.
AREAS COVERED: In this review, the benefits and limitations of MRI-guided endovascular interventions are addressed, systems and devices for guiding such interventions are summarized, and clinical applications are discussed. ...Translational research and further prec …
AREAS COVERED: In this review, the benefits and limitations of MRI-guided endovascular interventions are addressed, systems and devic …
27,552 results
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