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The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants.
van Gisbergen KP, Klarenbeek PL, Kragten NA, Unger PP, Nieuwenhuis MB, Wensveen FM, ten Brinke A, Tak PP, Eldering E, Nolte MA, van Lier RA. van Gisbergen KP, et al. Among authors: ten brinke a. Immunity. 2011 Jul 22;35(1):97-108. doi: 10.1016/j.immuni.2011.04.020. Epub 2011 Jul 14. Immunity. 2011. PMID: 21763160 Free article.
CD8⁺ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung.
Piet B, de Bree GJ, Smids-Dierdorp BS, van der Loos CM, Remmerswaal EB, von der Thüsen JH, van Haarst JM, Eerenberg JP, ten Brinke A, van der Bij W, Timens W, van Lier RA, Jonkers RE. Piet B, et al. Among authors: ten brinke a. J Clin Invest. 2011 Jun;121(6):2254-63. doi: 10.1172/JCI44675. Epub 2011 May 2. J Clin Invest. 2011. PMID: 21537083 Free PMC article.
Human virus-specific effector-type T cells accumulate in blood but not in lymph nodes.
Remmerswaal EB, Havenith SH, Idu MM, van Leeuwen EM, van Donselaar KA, Ten Brinke A, van der Bom-Baylon N, Bemelman FJ, van Lier RA, Ten Berge IJ. Remmerswaal EB, et al. Among authors: ten berge ij, ten brinke a. Blood. 2012 Feb 16;119(7):1702-12. doi: 10.1182/blood-2011-09-381574. Epub 2011 Dec 29. Blood. 2012. PMID: 22207739 Free article.
Deep sequencing of antiviral T-cell responses to HCMV and EBV in humans reveals a stable repertoire that is maintained for many years.
Klarenbeek PL, Remmerswaal EB, ten Berge IJ, Doorenspleet ME, van Schaik BD, Esveldt RE, Koch SD, ten Brinke A, van Kampen AH, Bemelman FJ, Tak PP, Baas F, de Vries N, van Lier RA. Klarenbeek PL, et al. Among authors: ten berge ij, ten brinke a. PLoS Pathog. 2012 Sep;8(9):e1002889. doi: 10.1371/journal.ppat.1002889. Epub 2012 Sep 27. PLoS Pathog. 2012. PMID: 23028307 Free PMC article.
Clonal evolution of CD8+ T cell responses against latent viruses: relationship among phenotype, localization, and function.
Remmerswaal EB, Klarenbeek PL, Alves NL, Doorenspleet ME, van Schaik BD, Esveldt RE, Idu MM, van Leeuwen EM, van der Bom-Baylon N, van Kampen AH, Koch SD, Pircher H, Bemelman FJ, Ten Brinke A, Baas F, Ten Berge IJ, van Lier RA, de Vries N. Remmerswaal EB, et al. Among authors: ten berge ij, ten brinke a. J Virol. 2015 Jan;89(1):568-80. doi: 10.1128/JVI.02003-14. Epub 2014 Oct 22. J Virol. 2015. PMID: 25339770 Free PMC article.
A central role for Notch in effector CD8(+) T cell differentiation.
Backer RA, Helbig C, Gentek R, Kent A, Laidlaw BJ, Dominguez CX, de Souza YS, van Trierum SE, van Beek R, Rimmelzwaan GF, ten Brinke A, Willemsen AM, van Kampen AH, Kaech SM, Blander JM, van Gisbergen K, Amsen D. Backer RA, et al. Among authors: ten brinke a. Nat Immunol. 2014 Dec;15(12):1143-51. doi: 10.1038/ni.3027. Epub 2014 Oct 26. Nat Immunol. 2014. PMID: 25344724 Free PMC article.
184 results