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In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation.
Vink PM, Smout WM, Driessen-Engels LJ, de Bruin AM, Delsing D, Krajnc-Franken MA, Jansen AJ, Rovers EF, van Puijenbroek AA, Kaptein A, Nolte MA, Garritsen A, van Eenennaam H. Vink PM, et al. Among authors: van puijenbroek aa, van eenennaam h. PLoS One. 2013;8(3):e57348. doi: 10.1371/journal.pone.0057348. Epub 2013 Mar 7. PLoS One. 2013. PMID: 23505428 Free PMC article.
PD-1 blockade augments Th1 and Th17 and suppresses Th2 responses in peripheral blood from patients with prostate and advanced melanoma cancer.
Dulos J, Carven GJ, van Boxtel SJ, Evers S, Driessen-Engels LJ, Hobo W, Gorecka MA, de Haan AF, Mulders P, Punt CJ, Jacobs JF, Schalken JA, Oosterwijk E, van Eenennaam H, Boots AM. Dulos J, et al. Among authors: van boxtel sj, van eenennaam h. J Immunother. 2012 Feb-Mar;35(2):169-78. doi: 10.1097/CJI.0b013e318247a4e7. J Immunother. 2012. PMID: 22306905
p38 inhibition and not MK2 inhibition enhances the secretion of chemokines from TNF-α activated rheumatoid arthritis fibroblast-like synoviocytes.
Dulos J, Wijnands FP, van den Hurk-van Alebeek JA, van Vugt MJ, Rullmann JA, Schot JJ, de Groot MW, Wagenaars JL, van Ravestein-van Os R, Smets RL, Vink PM, Hofstra CL, Nelissen RL, van Eenennaam H. Dulos J, et al. Among authors: van ravestein van os r, van den hurk van alebeek ja, van vugt mj, van eenennaam h. Clin Exp Rheumatol. 2013 Jul-Aug;31(4):515-25. Epub 2013 Apr 3. Clin Exp Rheumatol. 2013. PMID: 23558031
Human TLR10 is an anti-inflammatory pattern-recognition receptor.
Oosting M, Cheng SC, Bolscher JM, Vestering-Stenger R, Plantinga TS, Verschueren IC, Arts P, Garritsen A, van Eenennaam H, Sturm P, Kullberg BJ, Hoischen A, Adema GJ, van der Meer JW, Netea MG, Joosten LA. Oosting M, et al. Among authors: van eenennaam h, van der meer jw. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4478-84. doi: 10.1073/pnas.1410293111. Epub 2014 Oct 6. Proc Natl Acad Sci U S A. 2014. PMID: 25288745 Free PMC article.
Functional characterization of the selective pan-allele anti-SIRPα antibody ADU-1805 that blocks the SIRPα-CD47 innate immune checkpoint.
Voets E, Paradé M, Lutje Hulsik D, Spijkers S, Janssen W, Rens J, Reinieren-Beeren I, van den Tillaart G, van Duijnhoven S, Driessen L, Habraken M, van Zandvoort P, Kreijtz J, Vink P, van Elsas A, van Eenennaam H. Voets E, et al. Among authors: van duijnhoven s, van eenennaam h, van zandvoort p, van elsas a, van den tillaart g. J Immunother Cancer. 2019 Dec 4;7(1):340. doi: 10.1186/s40425-019-0772-0. J Immunother Cancer. 2019. PMID: 31801627 Free PMC article.
Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy.
Guelen L, Fischmann TO, Wong J, Mauze S, Guadagnoli M, Bąbała N, Wagenaars J, Juan V, Rosen D, Prosise W, Habraken M, Lodewijks I, Gu D, Stammen-Vogelzangs J, Yu Y, Baker J, Lutje Hulsik D, Driessen-Engels L, Malashock D, Kreijtz J, Bertens A, de Vries E, Bovens A, Bramer A, Zhang Y, Wnek R, Troth S, Chartash E, Dobrenkov K, Sadekova S, van Elsas A, Cheung JK, Fayadat-Dilman L, Borst J, Beebe AM, Van Eenennaam H. Guelen L, et al. Among authors: van eenennaam h. J Immunother Cancer. 2022 Sep;10(9):e005049. doi: 10.1136/jitc-2022-005049. J Immunother Cancer. 2022. PMID: 36100308 Free PMC article.
Integrated Single-Cell (Phospho-)Protein and RNA Detection Uncovers Phenotypic Characteristics and Active Signal Transduction of Human Antibody-Secreting Cells.
van Buijtenen E, Janssen W, Vink P, Habraken MJM, Wingens LJA, van Elsas A, Huck WTS, van Buggenum JAGL, van Eenennaam H. van Buijtenen E, et al. Among authors: van eenennaam h. Mol Cell Proteomics. 2023 Feb;22(2):100492. doi: 10.1016/j.mcpro.2023.100492. Epub 2023 Jan 7. Mol Cell Proteomics. 2023. PMID: 36623694 Free PMC article.
39 results