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(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides are orally active inhibitors of pyruvate dehydrogenase kinase.
J Med Chem. 1999 Jul 29;42(15):2741-6. doi: 10.1021/jm9902584.
J Med Chem. 1999.
PMID: 10425084
No abstract available.
Hypoglycemic prodrugs of 4-(2,2-dimethyl-1-oxopropyl)benzoic acid.
Aicher TD, Bebernitz GR, Bell PA, Brand LJ, Dain JG, Deems R, Fillers WS, Foley JE, Knorr DC, Nadelson J, Otero DA, Simpson R, Strohschein RJ, Young DA.
Aicher TD, et al. Among authors: strohschein rj.
J Med Chem. 1999 Jan 14;42(1):153-63. doi: 10.1021/jm980438y.
J Med Chem. 1999.
PMID: 9888840
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Anilides of (R)-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase.
Bebernitz GR, Aicher TD, Stanton JL, Gao J, Shetty SS, Knorr DC, Strohschein RJ, Tan J, Brand LJ, Liu C, Wang WH, Vinluan CC, Kaplan EL, Dragland CJ, DelGrande D, Islam A, Lozito RJ, Liu X, Maniara WM, Mann WR.
Bebernitz GR, et al. Among authors: strohschein rj.
J Med Chem. 2000 Jun 1;43(11):2248-57. doi: 10.1021/jm0000923.
J Med Chem. 2000.
PMID: 10841803
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Reduction in glucose levels in STZ diabetic rats by 4-(2,2-dimethyl-1-oxopropyl)benzoic acid: a prodrug approach for targeting the liver.
Bebernitz GR, Dain JG, Deems RO, Otero DA, Simpson WR, Strohschein RJ.
Bebernitz GR, et al. Among authors: strohschein rj.
J Med Chem. 2001 Feb 15;44(4):512-23. doi: 10.1021/jm000264w.
J Med Chem. 2001.
PMID: 11170641
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The effect of 1,3-diaryl-[1H]-pyrazole-4-acetamides on glucose utilization in ob/ob mice.
Bebernitz GR, Argentieri G, Battle B, Brennan C, Balkan B, Burkey BF, Eckhardt M, Gao J, Kapa P, Strohschein RJ, Schuster HF, Wilson M, Xu DD.
Bebernitz GR, et al. Among authors: strohschein rj.
J Med Chem. 2001 Aug 2;44(16):2601-11. doi: 10.1021/jm010032c.
J Med Chem. 2001.
PMID: 11472214
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Novel tricyclic systems. Oxazole, thiazole, and imidazole analogs of the amitriptyline type.
Galantay EE, Simpson R, Corriveau G, Denzer M, Knorr DC, Strohschein RJ, Paolella NA, Uike Y.
Galantay EE, et al. Among authors: strohschein rj.
J Med Chem. 1974 Dec;17(12):1316-27. doi: 10.1021/jm00258a018.
J Med Chem. 1974.
PMID: 4427328
No abstract available.
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