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The structure of mithramycin reinvestigated.
Wohlert SE, Künzel E, Machinek R, Méndez C, Salas JA, Rohr J. Wohlert SE, et al. Among authors: kunzel e. J Nat Prod. 1999 Jan;62(1):119-21. doi: 10.1021/np980355k. J Nat Prod. 1999. PMID: 9917296
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.
Lombó F, Künzel E, Prado L, Braña AF, Bindseil KU, Frevert J, Bearden D, Méndez C, Salas JA, Rohr J. Lombó F, et al. Among authors: kunzel e. Angew Chem Int Ed Engl. 2000 Feb;39(4):796-799. doi: 10.1002/(sici)1521-3773(20000218)39:4<796::aid-anie796>3.0.co;2-n. Angew Chem Int Ed Engl. 2000. PMID: 10760873 No abstract available.
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.
Remsing LL, Garcia-Bernardo J, Gonzalez A, Künzel E, Rix U, Braña AF, Bearden DW, Méndez C, Salas JA, Rohr J. Remsing LL, et al. Among authors: kunzel e. J Am Chem Soc. 2002 Feb 27;124(8):1606-14. doi: 10.1021/ja0105156. J Am Chem Soc. 2002. PMID: 11853433 Free PMC article.
The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster.
Hoffmeister D, Ichinose K, Domann S, Faust B, Trefzer A, Dräger G, Kirschning A, Fischer C, Künzel E, Bearden D, Rohr J, Bechthold A. Hoffmeister D, et al. Among authors: kunzel e. Chem Biol. 2000 Nov;7(11):821-31. doi: 10.1016/s1074-5521(00)00029-6. Chem Biol. 2000. PMID: 11094336
Function of glycosyltransferase genes involved in urdamycin A biosynthesis.
Trefzer A, Hoffmeister D, Künzel E, Stockert S, Weitnauer G, Westrich L, Rix U, Fuchser J, Bindseil KU, Rohr J, Bechthold A. Trefzer A, et al. Among authors: kunzel e. Chem Biol. 2000 Feb;7(2):133-42. doi: 10.1016/s1074-5521(00)00079-x. Chem Biol. 2000. PMID: 10662691
37 results