Zwart E - Search Results

1

Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development.

Wijnhoven SW, Zwart E, Speksnijder EN, Beems RB, Olive KP, Tuveson DA, Jonkers J, Schaap MM, van den Berg J, Jacks T, van Steeg H, de Vries A. Wijnhoven SW, et al. Among authors: zwart e. Cancer Res. 2005 Sep 15;65(18):8166-73. doi: 10.1158/0008-5472.CAN-05-1650. Cancer Res. 2005. PMID: 16166291

2

Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice.

Iwakuma T, Parant JM, Fasulo M, Zwart E, Jacks T, de Vries A, Lozano G. Iwakuma T, et al. Among authors: zwart e. Oncogene. 2004 Oct 7;23(46):7644-50. doi: 10.1038/sj.onc.1207793. Oncogene. 2004. PMID: 15361844

3

Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.

Bruins W, Zwart E, Attardi LD, Iwakuma T, Hoogervorst EM, Beems RB, Miranda B, van Oostrom CT, van den Berg J, van den Aardweg GJ, Lozano G, van Steeg H, Jacks T, de Vries A. Bruins W, et al. Among authors: zwart e. Mol Cell Biol. 2004 Oct;24(20):8884-94. doi: 10.1128/MCB.24.20.8884-8894.2004. Mol Cell Biol. 2004. PMID: 15456863 Free PMC article.

4

Lack of p53 Ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-induced bladder tumors but not ionizing radiation-induced lymphomas.

Hoogervorst EM, Bruins W, Zwart E, van Oostrom CT, van den Aardweg GJ, Beems RB, van den Berg J, Jacks T, van Steeg H, de Vries A. Hoogervorst EM, et al. Among authors: zwart e. Cancer Res. 2005 May 1;65(9):3610-6. doi: 10.1158/0008-5472.CAN-04-4328. Cancer Res. 2005. PMID: 15867355

5

Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage.

Wijnhoven SW, Speksnijder EN, Liu X, Zwart E, vanOostrom CT, Beems RB, Hoogervorst EM, Schaap MM, Attardi LD, Jacks T, van Steeg H, Jonkers J, de Vries A. Wijnhoven SW, et al. Among authors: zwart e. Cancer Res. 2007 May 15;67(10):4648-56. doi: 10.1158/0008-5472.CAN-06-4681. Cancer Res. 2007. PMID: 17510390

6

The absence of Ser389 phosphorylation in p53 affects the basal gene expression level of many p53-dependent genes and alters the biphasic response to UV exposure in mouse embryonic fibroblasts.

Bruins W, Bruning O, Jonker MJ, Zwart E, van der Hoeven TV, Pennings JL, Rauwerda H, de Vries A, Breit TM. Bruins W, et al. Among authors: zwart e. Mol Cell Biol. 2008 Mar;28(6):1974-87. doi: 10.1128/MCB.01610-07. Epub 2008 Jan 14. Mol Cell Biol. 2008. PMID: 18195040 Free PMC article.

7

lacZ mouse embryonic fibroblasts detect both clastogens and mutagens.

Mahabir AG, Zwart E, Schaap M, van Benthem J, de Vries A, Hernandez LG, Hendriksen CF, van Steeg H. Mahabir AG, et al. Among authors: zwart e. Mutat Res. 2009 Jun 18;666(1-2):50-6. doi: 10.1016/j.mrfmmm.2009.04.005. Epub 2009 Apr 23. Mutat Res. 2009. PMID: 19393670

8

Evaluation of benzo(a)pyrene-induced gene mutations in male germ cells.

Verhofstad N, van Oostrom CT, Zwart E, Maas LM, van Benthem J, van Schooten FJ, van Steeg H, Godschalk RW. Verhofstad N, et al. Among authors: zwart e. Toxicol Sci. 2011 Jan;119(1):218-23. doi: 10.1093/toxsci/kfq325. Epub 2010 Oct 20. Toxicol Sci. 2011. PMID: 20961952

9

Genotoxic exposure: novel cause of selection for a functional ΔN-p53 isoform.

Melis JP, Hoogervorst EM, van Oostrom CT, Zwart E, Breit TM, Pennings JL, de Vries A, van Steeg H. Melis JP, et al. Among authors: zwart e. Oncogene. 2011 Apr 14;30(15):1764-72. doi: 10.1038/onc.2010.552. Epub 2010 Dec 13. Oncogene. 2011. PMID: 21151170

10

Proliferating primary hepatocytes from the pUR288 lacZ plasmid mouse are valuable tools for genotoxicity assessment in vitro.

Zwart EP, Schaap MM, van den Dungen MW, Braakhuis HM, White PA, van Steeg H, van Benthem J, Luijten M. Zwart EP, et al. Environ Mol Mutagen. 2012 Jun;53(5):1-8. doi: 10.1002/em.21700. Epub 2012 May 23. Environ Mol Mutagen. 2012. PMID: 22619112

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