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Identification of a series of benzoxazoles as potent 5-HT6 ligands.
Liu KG, Lo JR, Comery TA, Zhang GM, Zhang JY, Kowal DM, Smith DL, Di L, Kerns EH, Schechter LE, Robichaud AJ. Liu KG, et al. Among authors: kerns eh. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1115-7. doi: 10.1016/j.bmcl.2008.12.107. Epub 2009 Jan 3. Bioorg Med Chem Lett. 2009. PMID: 19152787
1-Sulfonylindazoles as potent and selective 5-HT6 ligands.
Liu KG, Lo JR, Comery TA, Zhang GM, Zhang JY, Kowal DM, Smith DL, Di L, Kerns EH, Schechter LE, Robichaud AJ. Liu KG, et al. Among authors: kerns eh. Bioorg Med Chem Lett. 2009 May 1;19(9):2413-5. doi: 10.1016/j.bmcl.2009.03.071. Epub 2009 Mar 21. Bioorg Med Chem Lett. 2009. PMID: 19345582
Discovery of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134)13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation.
Butera JA, Larsen BD, Hennan JK, Kerns E, Di L, Alimardanov A, Swillo RE, Morgan GA, Liu K, Wang Q, Rossman EI, Unwalla R, McDonald L, Huselton C, Petersen JS. Butera JA, et al. J Med Chem. 2009 Feb 26;52(4):908-11. doi: 10.1021/jm801558d. J Med Chem. 2009. PMID: 19175320
Pharmaceutical profiling in drug discovery.
Kerns EH, Di L. Kerns EH, et al. Drug Discov Today. 2003 Apr 1;8(7):316-23. doi: 10.1016/s1359-6446(03)02649-7. Drug Discov Today. 2003. PMID: 12654544
Profiling drug-like properties in discovery research.
Di L, Kerns EH. Di L, et al. Among authors: kerns eh. Curr Opin Chem Biol. 2003 Jun;7(3):402-8. doi: 10.1016/s1367-5931(03)00055-3. Curr Opin Chem Biol. 2003. PMID: 12826129 Review.
79 results