Summy J - Search Results

1

Phosphate ester hydrolysis of biologically relevant molecules by cerium oxide nanoparticles.

Kuchma MH, Komanski CB, Colon J, Teblum A, Masunov AE, Alvarado B, Babu S, Seal S, Summy J, Baker CH. Kuchma MH, et al. Among authors: summy j. Nanomedicine. 2010 Dec;6(6):738-44. doi: 10.1016/j.nano.2010.05.004. Epub 2010 May 27. Nanomedicine. 2010. PMID: 20553964

2

Loss of tyrosine phosphatase-dependent inhibition promotes activation of tyrosine kinase c-Src in detached pancreatic cells.

Connelly SF, Isley BA, Baker CH, Gallick GE, Summy JM. Connelly SF, et al. Among authors: summy jm. Mol Carcinog. 2010 Dec;49(12):1007-21. doi: 10.1002/mc.20684. Mol Carcinog. 2010. PMID: 20945416 Free PMC article.

3

c-Src regulates constitutive and EGF-mediated VEGF expression in pancreatic tumor cells through activation of phosphatidyl inositol-3 kinase and p38 MAPK.

Summy JM, Trevino JG, Baker CH, Gallick GE. Summy JM, et al. Pancreas. 2005 Oct;31(3):263-74. doi: 10.1097/01.mpa.0000178280.50534.0c. Pancreas. 2005. PMID: 16163059

4

AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes.

Summy JM, Trevino JG, Lesslie DP, Baker CH, Shakespeare WC, Wang Y, Sundaramoorthi R, Metcalf CA 3rd, Keats JA, Sawyer TK, Gallick GE. Summy JM, et al. Mol Cancer Ther. 2005 Dec;4(12):1900-11. doi: 10.1158/1535-7163.MCT-05-0171. Mol Cancer Ther. 2005. PMID: 16373705

5

Inhibition of PDGFR phosphorylation and Src and Akt activity by GN963 leads to therapy of human pancreatic cancer growing orthotopically in nude mice.

Baker CH, Trevino JG, Summy JM, Zhang F, Caron A, Nesbit M, Gallick GE, Fidler IJ. Baker CH, et al. Among authors: summy jm. Int J Oncol. 2006 Jul;29(1):125-38. Int J Oncol. 2006. PMID: 16773192

6

Expression and activity of SRC regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis.

Trevino JG, Summy JM, Gray MJ, Nilsson MB, Lesslie DP, Baker CH, Gallick GE. Trevino JG, et al. Among authors: summy jm. Cancer Res. 2005 Aug 15;65(16):7214-22. doi: 10.1158/0008-5472.CAN-04-3858. Cancer Res. 2005. PMID: 16103072

7

Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model.

Trevino JG, Summy JM, Lesslie DP, Parikh NU, Hong DS, Lee FY, Donato NJ, Abbruzzese JL, Baker CH, Gallick GE. Trevino JG, et al. Among authors: summy jm. Am J Pathol. 2006 Mar;168(3):962-72. doi: 10.2353/ajpath.2006.050570. Am J Pathol. 2006. PMID: 16507911 Free PMC article.

8

Targeting the yin and the yang: combined inhibition of the tyrosine kinase c-Src and the tyrosine phosphatase SHP-2 disrupts pancreatic cancer signaling and biology in vitro and tumor formation in vivo.

Gomes EG, Connelly SF, Summy JM. Gomes EG, et al. Among authors: summy jm. Pancreas. 2013 Jul;42(5):795-806. doi: 10.1097/MPA.0b013e3182793fd7. Pancreas. 2013. PMID: 23271399

9

Src family kinases in tumor progression and metastasis.

Summy JM, Gallick GE. Summy JM, et al. Cancer Metastasis Rev. 2003 Dec;22(4):337-58. doi: 10.1023/a:1023772912750. Cancer Metastasis Rev. 2003. PMID: 12884910 Review.

10

SRC inhibitors as potential therapeutic agents for human cancers.

Trevino JG, Summy JM, Gallick GE. Trevino JG, et al. Among authors: summy jm. Mini Rev Med Chem. 2006 Jun;6(6):681-7. doi: 10.2174/138955706777435724. Mini Rev Med Chem. 2006. PMID: 16787379 Review.

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