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The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility.
Kiuchi T, Ortiz-Zapater E, Monypenny J, Matthews DR, Nguyen LK, Barbeau J, Coban O, Lawler K, Burford B, Rolfe DJ, de Rinaldis E, Dafou D, Simpson MA, Woodman N, Pinder S, Gillett CE, Devauges V, Poland SP, Fruhwirth G, Marra P, Boersma YL, Plückthun A, Gullick WJ, Yarden Y, Santis G, Winn M, Kholodenko BN, Martin-Fernandez ML, Parker P, Tutt A, Ameer-Beg SM, Ng T. Kiuchi T, et al. Among authors: winn m. Sci Signal. 2014 Aug 19;7(339):ra78. doi: 10.1126/scisignal.2005157. Sci Signal. 2014. PMID: 25140053
Effect of phosphorylation on EGFR dimer stability probed by single-molecule dynamics and FRET/FLIM.
Coban O, Zanetti-Dominguez LC, Matthews DR, Rolfe DJ, Weitsman G, Barber PR, Barbeau J, Devauges V, Kampmeier F, Winn M, Vojnovic B, Parker PJ, Lidke KA, Lidke DS, Ameer-Beg SM, Martin-Fernandez ML, Ng T. Coban O, et al. Among authors: winn m. Biophys J. 2015 Mar 10;108(5):1013-26. doi: 10.1016/j.bpj.2015.01.005. Biophys J. 2015. PMID: 25762314 Free PMC article.
EGFR oligomerization organizes kinase-active dimers into competent signalling platforms.
Needham SR, Roberts SK, Arkhipov A, Mysore VP, Tynan CJ, Zanetti-Domingues LC, Kim ET, Losasso V, Korovesis D, Hirsch M, Rolfe DJ, Clarke DT, Winn MD, Lajevardipour A, Clayton AH, Pike LJ, Perani M, Parker PJ, Shan Y, Shaw DE, Martin-Fernandez ML. Needham SR, et al. Among authors: winn md. Nat Commun. 2016 Oct 31;7:13307. doi: 10.1038/ncomms13307. Nat Commun. 2016. PMID: 27796308 Free PMC article.
Evaluating the solution from MrBUMP and BALBES.
Keegan RM, Long F, Fazio VJ, Winn MD, Murshudov GN, Vagin AA. Keegan RM, et al. Among authors: winn md. Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):313-23. doi: 10.1107/S0907444911007530. Epub 2011 Mar 18. Acta Crystallogr D Biol Crystallogr. 2011. PMID: 21460449 Free PMC article.
392 results