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ASXL1 plays an important role in erythropoiesis.
Shi H, Yamamoto S, Sheng M, Bai J, Zhang P, Chen R, Chen S, Shi L, Abdel-Wahab O, Xu M, Zhou Y, Yang FC. Shi H, et al. Among authors: zhang p. Sci Rep. 2016 Jun 29;6:28789. doi: 10.1038/srep28789. Sci Rep. 2016. PMID: 27352931 Free PMC article.
ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis.
Li Z, Zhang P, Yan A, Guo Z, Ban Y, Li J, Chen S, Yang H, He Y, Li J, Guo Y, Zhang W, Hajiramezanali E, An H, Fajardo D, Harbour JW, Ruan Y, Nimer SD, Yu P, Chen X, Xu M, Yang FC. Li Z, et al. Among authors: zhang p, zhang w. Sci Adv. 2017 Jan 20;3(1):e1601602. doi: 10.1126/sciadv.1601602. eCollection 2017 Jan. Sci Adv. 2017. PMID: 28116354 Free PMC article.
Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies.
Yang H, Kurtenbach S, Guo Y, Lohse I, Durante MA, Li J, Li Z, Al-Ali H, Li L, Chen Z, Field MG, Zhang P, Chen S, Yamamoto S, Li Z, Zhou Y, Nimer SD, Harbour JW, Wahlestedt C, Xu M, Yang FC. Yang H, et al. Among authors: zhang p. Blood. 2018 Jan 18;131(3):328-341. doi: 10.1182/blood-2017-06-789669. Epub 2017 Nov 7. Blood. 2018. PMID: 29113963 Free PMC article.
Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC).
Chu Y, Zhao Z, Sant DW, Zhu G, Greenblatt SM, Liu L, Wang J, Cao Z, Tho JC, Chen S, Liu X, Zhang P, Maciejewski JP, Nimer S, Wang G, Yuan W, Yang FC, Xu M. Chu Y, et al. Among authors: zhang p. Genomics Proteomics Bioinformatics. 2018 Jun;16(3):172-186. doi: 10.1016/j.gpb.2018.04.005. Epub 2018 Jun 13. Genomics Proteomics Bioinformatics. 2018. PMID: 29908294 Free PMC article.
ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis.
Guo Y, Zhou Y, Yamatomo S, Yang H, Zhang P, Chen S, Nimer SD, Zhao ZJ, Xu M, Bai J, Yang FC. Guo Y, et al. Among authors: zhang p. Leukemia. 2019 May;33(5):1287-1291. doi: 10.1038/s41375-018-0347-y. Epub 2019 Jan 16. Leukemia. 2019. PMID: 30651633 No abstract available.
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