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mTOR is a key modulator of ageing and age-related disease.
Johnson SC, Rabinovitch PS, Kaeberlein M. Johnson SC, et al. Among authors: kaeberlein m. Nature. 2013 Jan 17;493(7432):338-45. doi: 10.1038/nature11861. Nature. 2013. PMID: 23325216 Free PMC article. Review.
Transcription errors induce proteotoxic stress and shorten cellular lifespan.
Vermulst M, Denney AS, Lang MJ, Hung CW, Moore S, Moseley MA, Thompson JW, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Caine J, Jorgenson J, Cyr D, Kaeberlein M, Strathern JN, Duncan MC, Erie DA. Vermulst M, et al. Among authors: kaeberlein m. Nat Commun. 2015 Aug 25;6:8065. doi: 10.1038/ncomms9065. Nat Commun. 2015. PMID: 26304740 Free PMC article.
Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans.
Bennett CF, Kwon JJ, Chen C, Russell J, Acosta K, Burnaevskiy N, Crane MM, Bitto A, Vander Wende H, Simko M, Pineda V, Rossner R, Wasko BM, Choi H, Chen S, Park S, Jafari G, Sands B, Perez Olsen C, Mendenhall AR, Morgan PG, Kaeberlein M. Bennett CF, et al. Among authors: kaeberlein m. PLoS Genet. 2017 Mar 29;13(3):e1006695. doi: 10.1371/journal.pgen.1006695. eCollection 2017 Mar. PLoS Genet. 2017. PMID: 28355222 Free PMC article.
Cell-to-cell variation in gene expression and the aging process.
Mendenhall AR, Martin GM, Kaeberlein M, Anderson RM. Mendenhall AR, et al. Among authors: kaeberlein m. Geroscience. 2021 Feb;43(1):181-196. doi: 10.1007/s11357-021-00339-9. Epub 2021 Feb 17. Geroscience. 2021. PMID: 33595768 Free PMC article. Review.
262 results