Smith MD - Search Results

1

Discovery of [¹¹C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases.

Tong L, Li W, Lo MM, Gao X, Wai JM, Rudd M, Tellers D, Joshi A, Zeng Z, Miller P, Salinas C, Riffel K, Haley H, Purcell M, Holahan M, Gantert L, Schubert JW, Jones K, Mulhearn J, Egbertson M, Meng Z, Hanney B, Gomez R, Harrison ST, McQuade P, Bueters T, Uslaner J, Morrow J, Thomson F, Kong J, Liao J, Selyutin O, Bao J, Hastings NB, Agrawal S, Magliaro BC, Monsma FJ Jr, Smith MD, Risso S, Hesk D, Hostetler E, Mazzola R. Tong L, et al. Among authors: smith md. J Med Chem. 2020 Mar 12;63(5):2411-2425. doi: 10.1021/acs.jmedchem.9b01406. Epub 2020 Mar 3. J Med Chem. 2020. PMID: 32101422 Free article.

2

Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists.

Qiang L, Sasikumar TK, Burnett DA, Su J, Tang H, Ye Y, Mazzola RD Jr, Zhu Z, McKittrick BA, Greenlee WJ, Fawzi A, Smith M, Zhang H, Lachowicz JE. Qiang L, et al. Bioorg Med Chem Lett. 2010 Feb 1;20(3):836-40. doi: 10.1016/j.bmcl.2009.12.100. Epub 2010 Jan 4. Bioorg Med Chem Lett. 2010. PMID: 20061148

3

High-Throughput Agonist Shift Assay Development for the Analysis of M₁-Positive Allosteric Modulators.

Homsher MF, Beshore DC, Cassaday J, Squadroni B, Mohammed E, Hartnett M, Day S, Ma L, Pechter D, Smith MD, Monsma F, Zuck P, Finley MF, Uebele VN, Hermes JD. Homsher MF, et al. Among authors: smith md. SLAS Discov. 2017 Sep;22(8):1060-1066. doi: 10.1177/2472555217705373. Epub 2017 Apr 20. SLAS Discov. 2017. PMID: 28426939 Free article.

4

Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors.

Zhou G, Ting PC, Wishart G, Zorn N, Aslanian RG, Lin M, Smith M, Walker SS, Cook J, Van Heek M, Lachowicz J. Zhou G, et al. Bioorg Med Chem Lett. 2014 Apr 1;24(7):1790-4. doi: 10.1016/j.bmcl.2014.02.028. Epub 2014 Feb 19. Bioorg Med Chem Lett. 2014. PMID: 24618302

5

ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999.

Zhang FL, Luo L, Gustafson E, Lachowicz J, Smith M, Qiao X, Liu YH, Chen G, Pramanik B, Laz TM, Palmer K, Bayne M, Monsma FJ Jr. Zhang FL, et al. J Biol Chem. 2001 Mar 16;276(11):8608-15. doi: 10.1074/jbc.M009718200. Epub 2000 Dec 4. J Biol Chem. 2001. PMID: 11104774 Free article.

6

Identification of 2-aminooxazole amides as acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) inhibitors through scaffold hopping strategy.

Kim HM, Smith MD, Kim JH, Caplen MA, Chan TY, McKittrick BA, Cook JA, van Heek M, Lachowicz J. Kim HM, et al. Among authors: smith md. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6410-4. doi: 10.1016/j.bmcl.2013.09.048. Epub 2013 Sep 25. Bioorg Med Chem Lett. 2013. PMID: 24120540

7

Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists.

Wu WL, Burnett DA, Spring R, Greenlee WJ, Smith M, Favreau L, Fawzi A, Zhang H, Lachowicz JE. Wu WL, et al. J Med Chem. 2005 Feb 10;48(3):680-93. doi: 10.1021/jm030614p. J Med Chem. 2005. PMID: 15689153

8

Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.

Ting PC, Lee JF, Zorn N, Kim HM, Aslanian RG, Lin M, Smith M, Walker SS, Cook J, Van Heek M, Lachowicz J. Ting PC, et al. Bioorg Med Chem Lett. 2013 Feb 15;23(4):985-8. doi: 10.1016/j.bmcl.2012.12.040. Epub 2012 Dec 21. Bioorg Med Chem Lett. 2013. PMID: 23317570

9

Remote functionalization of SCH 39166: discovery of potent and selective benzazepine dopamine D1 receptor antagonists.

Sasikumar TK, Burnett DA, Greenlee WJ, Smith M, Fawzi A, Zhang H, Lachowicz JE. Sasikumar TK, et al. Bioorg Med Chem Lett. 2010 Feb 1;20(3):832-5. doi: 10.1016/j.bmcl.2009.12.094. Epub 2010 Jan 4. Bioorg Med Chem Lett. 2010. PMID: 20064718

10

MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.

Fell MJ, Mirescu C, Basu K, Cheewatrakoolpong B, DeMong DE, Ellis JM, Hyde LA, Lin Y, Markgraf CG, Mei H, Miller M, Poulet FM, Scott JD, Smith MD, Yin Z, Zhou X, Parker EM, Kennedy ME, Morrow JA. Fell MJ, et al. Among authors: smith md. J Pharmacol Exp Ther. 2015 Dec;355(3):397-409. doi: 10.1124/jpet.115.227587. Epub 2015 Sep 25. J Pharmacol Exp Ther. 2015. PMID: 26407721

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