Costa A - Search Results

1

Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch.

Lehmann LC, Bacic L, Hewitt G, Brackmann K, Sabantsev A, Gaullier G, Pytharopoulou S, Degliesposti G, Okkenhaug H, Tan S, Costa A, Skehel JM, Boulton SJ, Deindl S. Lehmann LC, et al. Among authors: costa a. Cell Rep. 2020 Dec 22;33(12):108529. doi: 10.1016/j.celrep.2020.108529. Cell Rep. 2020. PMID: 33357431 Free PMC article.

2

The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2.

Swuec P, Renault L, Borg A, Shah F, Murphy VJ, van Twest S, Snijders AP, Deans AJ, Costa A. Swuec P, et al. Among authors: costa a. Cell Rep. 2017 Jan 17;18(3):611-623. doi: 10.1016/j.celrep.2016.11.013. Epub 2016 Dec 13. Cell Rep. 2017. PMID: 27986592 Free PMC article.

3

Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome.

Eickhoff P, Kose HB, Martino F, Petojevic T, Abid Ali F, Locke J, Tamberg N, Nans A, Berger JM, Botchan MR, Yardimci H, Costa A. Eickhoff P, et al. Among authors: costa a. Cell Rep. 2019 Sep 3;28(10):2673-2688.e8. doi: 10.1016/j.celrep.2019.07.104. Cell Rep. 2019. PMID: 31484077 Free PMC article.

4

Structural Studies Reveal the Functional Modularity of the Scc2-Scc4 Cohesin Loader.

Chao WC, Murayama Y, Muñoz S, Costa A, Uhlmann F, Singleton MR. Chao WC, et al. Among authors: costa a. Cell Rep. 2015 Aug 4;12(5):719-25. doi: 10.1016/j.celrep.2015.06.071. Epub 2015 Jul 23. Cell Rep. 2015. PMID: 26212329 Free article.

5

CMG-Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome.

Zhou JC, Janska A, Goswami P, Renault L, Abid Ali F, Kotecha A, Diffley JFX, Costa A. Zhou JC, et al. Among authors: costa a. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4141-4146. doi: 10.1073/pnas.1700530114. Epub 2017 Apr 3. Proc Natl Acad Sci U S A. 2017. PMID: 28373564 Free PMC article.

6

Cryo-electron microscopy of chromatin biology.

Wilson MD, Costa A. Wilson MD, et al. Among authors: costa a. Acta Crystallogr D Struct Biol. 2017 Jun 1;73(Pt 6):541-548. doi: 10.1107/S2059798317004430. Epub 2017 Apr 20. Acta Crystallogr D Struct Biol. 2017. PMID: 28580916 Free PMC article. Review.

7

Cdt1 stabilizes an open MCM ring for helicase loading.

Frigola J, He J, Kinkelin K, Pye VE, Renault L, Douglas ME, Remus D, Cherepanov P, Costa A, Diffley JFX. Frigola J, et al. Among authors: costa a. Nat Commun. 2017 Jun 23;8:15720. doi: 10.1038/ncomms15720. Nat Commun. 2017. PMID: 28643783 Free PMC article.

8

Cryo-EM structure of a licensed DNA replication origin.

Abid Ali F, Douglas ME, Locke J, Pye VE, Nans A, Diffley JFX, Costa A. Abid Ali F, et al. Among authors: costa a. Nat Commun. 2017 Dec 21;8(1):2241. doi: 10.1038/s41467-017-02389-0. Nat Commun. 2017. PMID: 29269875 Free PMC article.

9

The mechanism of eukaryotic CMG helicase activation.

Douglas ME, Ali FA, Costa A, Diffley JFX. Douglas ME, et al. Among authors: costa a. Nature. 2018 Mar 8;555(7695):265-268. doi: 10.1038/nature25787. Epub 2018 Feb 28. Nature. 2018. PMID: 29489749 Free PMC article.

10

Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome.

Goswami P, Abid Ali F, Douglas ME, Locke J, Purkiss A, Janska A, Eickhoff P, Early A, Nans A, Cheung AMC, Diffley JFX, Costa A. Goswami P, et al. Among authors: costa a. Nat Commun. 2018 Nov 29;9(1):5061. doi: 10.1038/s41467-018-07417-1. Nat Commun. 2018. PMID: 30498216 Free PMC article.

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