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Nephrotic Syndrome Gene TBC1D8B Is Required for Endosomal Maturation and Nephrin Endocytosis in Drosophila.
Milosavljevic J, Lempicki C, Lang K, Heinkele H, Kampf LL, Leroy C, Chen M, Gerstner L, Spitz D, Wang M, Knob AU, Kayser S, Helmstädter M, Walz G, Pollak MR, Hermle T. Milosavljevic J, et al. Among authors: helmstadter m. J Am Soc Nephrol. 2022 Dec;33(12):2174-2193. doi: 10.1681/ASN.2022030275. Epub 2022 Sep 22. J Am Soc Nephrol. 2022. PMID: 36137753 Free PMC article.
aPKCλ/ι and aPKCζ contribute to podocyte differentiation and glomerular maturation.
Hartleben B, Widmeier E, Suhm M, Worthmann K, Schell C, Helmstädter M, Wiech T, Walz G, Leitges M, Schiffer M, Huber TB. Hartleben B, et al. Among authors: helmstadter m. J Am Soc Nephrol. 2013 Feb;24(2):253-67. doi: 10.1681/ASN.2012060582. Epub 2013 Jan 18. J Am Soc Nephrol. 2013. PMID: 23334392 Free PMC article.
N-wasp is required for stabilization of podocyte foot processes.
Schell C, Baumhakl L, Salou S, Conzelmann AC, Meyer C, Helmstädter M, Wrede C, Grahammer F, Eimer S, Kerjaschki D, Walz G, Snapper S, Huber TB. Schell C, et al. Among authors: helmstadter m. J Am Soc Nephrol. 2013 Apr;24(5):713-21. doi: 10.1681/ASN.2012080844. Epub 2013 Mar 7. J Am Soc Nephrol. 2013. PMID: 23471198 Free PMC article.
Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis.
Bechtel W, Helmstädter M, Balica J, Hartleben B, Kiefer B, Hrnjic F, Schell C, Kretz O, Liu S, Geist F, Kerjaschki D, Walz G, Huber TB. Bechtel W, et al. Among authors: helmstadter m. J Am Soc Nephrol. 2013 Apr;24(5):727-43. doi: 10.1681/ASN.2012070700. Epub 2013 Mar 14. J Am Soc Nephrol. 2013. PMID: 23492732 Free PMC article.
TBC1D8B Mutations Implicate RAB11-Dependent Vesicular Trafficking in the Pathogenesis of Nephrotic Syndrome.
Kampf LL, Schneider R, Gerstner L, Thünauer R, Chen M, Helmstädter M, Amar A, Onuchic-Whitford AC, Loza Munarriz R, Berdeli A, Müller D, Schrezenmeier E, Budde K, Mane S, Laricchia KM, Rehm HL, MacArthur DG, Lifton RP, Walz G, Römer W, Bergmann C, Hildebrandt F, Hermle T. Kampf LL, et al. Among authors: helmstadter m. J Am Soc Nephrol. 2019 Dec;30(12):2338-2353. doi: 10.1681/ASN.2019040414. Epub 2019 Nov 15. J Am Soc Nephrol. 2019. PMID: 31732614 Free PMC article.
SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance.
Rogg M, Maier JI, Dotzauer R, Artelt N, Kretz O, Helmstädter M, Abed A, Sammarco A, Sigle A, Sellung D, Dinse P, Reiche K, Yasuda-Yamahara M, Biniossek ML, Walz G, Werner M, Endlich N, Schilling O, Huber TB, Schell C. Rogg M, et al. Among authors: helmstadter m. J Am Soc Nephrol. 2021 Mar;32(3):563-579. doi: 10.1681/ASN.2020081126. Epub 2021 Jan 29. J Am Soc Nephrol. 2021. PMID: 33514561 Free PMC article.
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