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Delta Opioid Receptor-Mediated Antidepressant-Like Effects of Diprenorphine in Mice.
Olson KM, Hillhouse TM, Burgess GE, West JL, Hallahan JE, Dripps IJ, Ladetto AG, Rice KC, Jutkiewicz EM, Traynor JR. Olson KM, et al. Among authors: hillhouse tm. J Pharmacol Exp Ther. 2023 Mar;384(3):343-352. doi: 10.1124/jpet.122.001182. Epub 2022 Dec 1. J Pharmacol Exp Ther. 2023. PMID: 36456196 Free PMC article.
C7β-methyl analogues of the orvinols: the discovery of kappa opioid antagonists with nociceptin/orphanin FQ peptide (NOP) receptor partial agonism and low, or zero, efficacy at mu opioid receptors.
Cueva JP, Roche C, Ostovar M, Kumar V, Clark MJ, Hillhouse TM, Lewis JW, Traynor JR, Husbands SM. Cueva JP, et al. Among authors: hillhouse tm. J Med Chem. 2015 May 28;58(10):4242-9. doi: 10.1021/acs.jmedchem.5b00130. Epub 2015 May 6. J Med Chem. 2015. PMID: 25898137 Free PMC article.
Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects.
Kandasamy R, Hillhouse TM, Livingston KE, Kochan KE, Meurice C, Eans SO, Li MH, White AD, Roques BP, McLaughlin JP, Ingram SL, Burford NT, Alt A, Traynor JR. Kandasamy R, et al. Among authors: hillhouse tm. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2000017118. doi: 10.1073/pnas.2000017118. Proc Natl Acad Sci U S A. 2021. PMID: 33846240 Free PMC article.
Opioid receptor system contributes to the acute and sustained antidepressant-like effects, but not the hyperactivity motor effects of ketamine in mice.
Zhang F, Hillhouse TM, Anderson PM, Koppenhaver PO, Kegen TN, Manicka SG, Lane JT, Pottanat E, Van Fossen M, Rice R, Porter JH. Zhang F, et al. Among authors: hillhouse tm. Pharmacol Biochem Behav. 2021 Sep;208:173228. doi: 10.1016/j.pbb.2021.173228. Epub 2021 Jul 2. Pharmacol Biochem Behav. 2021. PMID: 34224734
32 results