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Page 1
The Gut Microbial Metabolite Trimethylamine N -oxide, Incident CKD, and Kidney Function Decline.
Wang M, Tang WHW, Li XS, de Oliveira Otto MC, Lee Y, Lemaitre RN, Fretts A, Nemet I, Sotoodehnia N, Sitlani CM, Budoff M, DiDonato JA, Wang Z, Bansal N, Shlipak MG, Psaty BM, Siscovick DS, Sarnak MJ, Mozaffarian D, Hazen SL. Wang M, et al. Among authors: didonato ja. J Am Soc Nephrol. 2024 Jun 1;35(6):749-760. doi: 10.1681/ASN.0000000000000344. Epub 2024 May 9. J Am Soc Nephrol. 2024. PMID: 38593157 No abstract available.
Longitudinal Plasma Measures of Trimethylamine N-Oxide and Risk of Atherosclerotic Cardiovascular Disease Events in Community-Based Older Adults.
Lee Y, Nemet I, Wang Z, Lai HTM, de Oliveira Otto MC, Lemaitre RN, Fretts AM, Sotoodehnia N, Budoff M, DiDonato JA, McKnight B, Tang WHW, Psaty BM, Siscovick DS, Hazen SL, Mozaffarian D. Lee Y, et al. Among authors: didonato ja. J Am Heart Assoc. 2021 Sep 7;10(17):e020646. doi: 10.1161/JAHA.120.020646. Epub 2021 Aug 16. J Am Heart Assoc. 2021. PMID: 34398665 Free PMC article.
Association of Trimethylamine N-Oxide and Metabolites With Mortality in Older Adults.
Fretts AM, Hazen SL, Jensen P, Budoff M, Sitlani CM, Wang M, de Oliveira Otto MC, DiDonato JA, Lee Y, Psaty BM, Siscovick DS, Sotoodehnia N, Tang WHW, Lai H, Lemaitre RN, Mozaffarian D. Fretts AM, et al. Among authors: didonato ja. JAMA Netw Open. 2022 May 2;5(5):e2213242. doi: 10.1001/jamanetworkopen.2022.13242. JAMA Netw Open. 2022. PMID: 35594043 Free PMC article.
Dietary Meat, Trimethylamine N-Oxide-Related Metabolites, and Incident Cardiovascular Disease Among Older Adults: The Cardiovascular Health Study.
Wang M, Wang Z, Lee Y, Lai HTM, de Oliveira Otto MC, Lemaitre RN, Fretts A, Sotoodehnia N, Budoff M, DiDonato JA, McKnight B, Tang WHW, Psaty BM, Siscovick DS, Hazen SL, Mozaffarian D. Wang M, et al. Among authors: didonato ja. Arterioscler Thromb Vasc Biol. 2022 Sep;42(9):e273-e288. doi: 10.1161/ATVBAHA.121.316533. Epub 2022 Aug 1. Arterioscler Thromb Vasc Biol. 2022. PMID: 35912635 Free PMC article.
A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors.
Nemet I, Saha PP, Gupta N, Zhu W, Romano KA, Skye SM, Cajka T, Mohan ML, Li L, Wu Y, Funabashi M, Ramer-Tait AE, Naga Prasad SV, Fiehn O, Rey FE, Tang WHW, Fischbach MA, DiDonato JA, Hazen SL. Nemet I, et al. Among authors: didonato ja. Cell. 2020 Mar 5;180(5):862-877.e22. doi: 10.1016/j.cell.2020.02.016. Cell. 2020. PMID: 32142679 Free PMC article.
Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease.
Gupta N, Buffa JA, Roberts AB, Sangwan N, Skye SM, Li L, Ho KJ, Varga J, DiDonato JA, Tang WHW, Hazen SL. Gupta N, et al. Among authors: didonato ja. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1239-1255. doi: 10.1161/ATVBAHA.120.314139. Epub 2020 Mar 26. Arterioscler Thromb Vasc Biol. 2020. PMID: 32212854 Free PMC article.
Gut microbes impact stroke severity via the trimethylamine N-oxide pathway.
Zhu W, Romano KA, Li L, Buffa JA, Sangwan N, Prakash P, Tittle AN, Li XS, Fu X, Androjna C, DiDonato AJ, Brinson K, Trapp BD, Fischbach MA, Rey FE, Hajjar AM, DiDonato JA, Hazen SL. Zhu W, et al. Among authors: didonato ja, didonato aj. Cell Host Microbe. 2021 Jul 14;29(7):1199-1208.e5. doi: 10.1016/j.chom.2021.05.002. Epub 2021 Jun 16. Cell Host Microbe. 2021. PMID: 34139173 Free PMC article.
Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis.
Witkowski M, Witkowski M, Friebel J, Buffa JA, Li XS, Wang Z, Sangwan N, Li L, DiDonato JA, Tizian C, Haghikia A, Kirchhofer D, Mach F, Räber L, Matter CM, Tang WHW, Landmesser U, Lüscher TF, Rauch U, Hazen SL. Witkowski M, et al. Among authors: didonato ja. Cardiovasc Res. 2022 Jul 27;118(10):2367-2384. doi: 10.1093/cvr/cvab263. Cardiovasc Res. 2022. PMID: 34352109 Free PMC article.
The microbial gbu gene cluster links cardiovascular disease risk associated with red meat consumption to microbiota L-carnitine catabolism.
Buffa JA, Romano KA, Copeland MF, Cody DB, Zhu W, Galvez R, Fu X, Ward K, Ferrell M, Dai HJ, Skye S, Hu P, Li L, Parlov M, McMillan A, Wei X, Nemet I, Koeth RA, Li XS, Wang Z, Sangwan N, Hajjar AM, Dwidar M, Weeks TL, Bergeron N, Krauss RM, Tang WHW, Rey FE, DiDonato JA, Gogonea V, Gerberick GF, Garcia-Garcia JC, Hazen SL. Buffa JA, et al. Among authors: didonato ja. Nat Microbiol. 2022 Jan;7(1):73-86. doi: 10.1038/s41564-021-01010-x. Epub 2021 Dec 23. Nat Microbiol. 2022. PMID: 34949826 Free PMC article.
Brief Report: Intestinal Microbiota-Produced Trimethylamine-N-Oxide and Its Association With Coronary Stenosis and HIV Serostatus.
Miller PE, Haberlen SA, Brown TT, Margolick JB, DiDonato JA, Hazen SL, Witt MD, Kingsley LA, Palella FJ Jr, Budoff M, Jacobson LP, Post WS, Sears CL. Miller PE, et al. Among authors: didonato ja. J Acquir Immune Defic Syndr. 2016 May 1;72(1):114-8. doi: 10.1097/QAI.0000000000000937. J Acquir Immune Defic Syndr. 2016. PMID: 26825179 Free PMC article.
106 results