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Discovery of an Ortho-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydronorthebaine Derivative as a Selective and Potent Kappa Opioid Receptor Agonist with Subsided Sedative Effect.
Li Z, Ye R, He Q, Lu J, Sun Y, Sun X, Tang S, Hu S, Chai J, Kong L, Liu X, Chen J, Fang Y, Lan Y, Xie Q, Liu J, Shao L, Fu W, Wang Y, Li W. Li Z, et al. Among authors: chai j. J Med Chem. 2024 May 9;67(9):7112-7129. doi: 10.1021/acs.jmedchem.3c02439. Epub 2024 Apr 22. J Med Chem. 2024. PMID: 38647397
Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic.
Huang H, Li X, Xie P, Li X, Xu X, Qian Y, Yuan C, Meng X, Chai J, Chen J, Liu J, Wang W, Li W, Wang Y, Fu W, Liu J. Huang H, et al. Among authors: chai j. J Med Chem. 2021 Jul 8;64(13):9458-9483. doi: 10.1021/acs.jmedchem.1c00722. Epub 2021 Jun 21. J Med Chem. 2021. PMID: 34152138
Discovery of an M-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile.
He Q, Wei Y, Liu X, Ye R, Kong L, Li Z, Jiang S, Yu L, Chai J, Xie Q, Fu W, Wang Y, Li W, Qiu Z, Liu J, Shao L. He Q, et al. Among authors: chai j. J Med Chem. 2021 Aug 26;64(16):12414-12433. doi: 10.1021/acs.jmedchem.1c01082. Epub 2021 Aug 13. J Med Chem. 2021. PMID: 34387468
Antinociceptive activities and mechanism of action of Cepharanthine.
Wei XY, Long JD, Chai JR, Chen J, Gao JP, Wang YJ, Liu JG. Wei XY, et al. Among authors: chai jr. Biochem Biophys Res Commun. 2022 Jul 23;614:219-224. doi: 10.1016/j.bbrc.2022.04.083. Epub 2022 May 6. Biochem Biophys Res Commun. 2022. PMID: 35636221
Pharmacological characterization and therapeutic potential for the treatment of opioid abuse with ATPM-ET, an N-ethyl substituted aminothiazolomorphinan with κ agonist and μ agonist/antagonist activity.
Sun JF, Wang YH, Chai JR, Li FY, Hang A, Lu G, Tao YM, Cheng Y, Chi ZQ, Neumeyer JL, Zhang A, Liu JG, Wang YJ. Sun JF, et al. Eur J Pharmacol. 2014 Oct 5;740:455-63. doi: 10.1016/j.ejphar.2014.06.045. Epub 2014 Jul 3. Eur J Pharmacol. 2014. PMID: 24998879
2,971 results