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Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression.
Craig JE, Han X, Qassim A, Hassall M, Cooke Bailey JN, Kinzy TG, Khawaja AP, An J, Marshall H, Gharahkhani P, Igo RP Jr, Graham SL, Healey PR, Ong JS, Zhou T, Siggs O, Law MH, Souzeau E, Ridge B, Hysi PG, Burdon KP, Mills RA, Landers J, Ruddle JB, Agar A, Galanopoulos A, White AJR, Willoughby CE, Andrew NH, Best S, Vincent AL, Goldberg I, Radford-Smith G, Martin NG, Montgomery GW, Vitart V, Hoehn R, Wojciechowski R, Jonas JB, Aung T, Pasquale LR, Cree AJ, Sivaprasad S, Vallabh NA; NEIGHBORHOOD consortium; UK Biobank Eye and Vision Consortium; Viswanathan AC, Pasutto F, Haines JL, Klaver CCW, van Duijn CM, Casson RJ, Foster PJ, Khaw PT, Hammond CJ, Mackey DA, Mitchell P, Lotery AJ, Wiggs JL, Hewitt AW, MacGregor S. Craig JE, et al. Among authors: agar a. Nat Genet. 2020 Feb;52(2):160-166. doi: 10.1038/s41588-019-0556-y. Epub 2020 Jan 20. Nat Genet. 2020. PMID: 31959993 Free PMC article.
Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance.
Awadalla MS, Fitzgerald J, Andrew NH, Zhou T, Marshall H, Qassim A, Hassall M, Casson RJ, Graham SL, Healey PR, Agar A, Galanopoulos A, Phipps S, Chappell A, Landers J, Craig JE. Awadalla MS, et al. Among authors: agar a. PLoS One. 2018 Dec 5;13(12):e0206684. doi: 10.1371/journal.pone.0206684. eCollection 2018. PLoS One. 2018. PMID: 30517101 Free PMC article. Clinical Trial.
Macular Ganglion Cell-Inner Plexiform Layer Loss Precedes Peripapillary Retinal Nerve Fiber Layer Loss in Glaucoma with Lower Intraocular Pressure.
Marshall HN, Andrew NH, Hassall M, Qassim A, Souzeau E, Ridge B, Nguyen T, Fitzgerald J, Awadalla MS, Burdon KP, Healey PR, Agar A, Galanopoulos A, Hewitt AW, Graham SL, Landers J, Casson RJ, Craig JE. Marshall HN, et al. Among authors: agar a. Ophthalmology. 2019 Aug;126(8):1119-1130. doi: 10.1016/j.ophtha.2019.03.016. Epub 2019 Mar 22. Ophthalmology. 2019. PMID: 30910584
An Intraocular Pressure Polygenic Risk Score Stratifies Multiple Primary Open-Angle Glaucoma Parameters Including Treatment Intensity.
Qassim A, Souzeau E, Siggs OM, Hassall MM, Han X, Griffiths HL, Frost NA, Vallabh NA, Kirwan JF, Menon G, Cree AJ, Galanopoulos A, Agar A, Healey PR, Graham SL, Landers J, Casson RJ, Gharahkhani P, Willoughby CE, Hewitt AW, Lotery AJ, MacGregor S, Craig JE. Qassim A, et al. Among authors: agar a. Ophthalmology. 2020 Jul;127(7):901-907. doi: 10.1016/j.ophtha.2019.12.025. Epub 2020 Jan 7. Ophthalmology. 2020. PMID: 32081492
Cardiovascular Disease Predicts Structural and Functional Progression in Early Glaucoma.
Marshall H, Mullany S, Qassim A, Siggs O, Hassall M, Ridge B, Nguyen T, Awadalla M, Andrew NH, Healey PR, Agar A, Galanopoulos A, Hewitt AW, MacGregor S, Graham SL, Mills R, Shulz A, Landers J, Casson RJ, Craig JE. Marshall H, et al. Among authors: agar a. Ophthalmology. 2021 Jan;128(1):58-69. doi: 10.1016/j.ophtha.2020.06.067. Epub 2020 Jul 28. Ophthalmology. 2021. PMID: 32730956
Corneal Stiffness Parameters Are Predictive of Structural and Functional Progression in Glaucoma Suspect Eyes.
Qassim A, Mullany S, Abedi F, Marshall H, Hassall MM, Kolovos A, Knight LSW, Nguyen T, Awadalla MS, Chappell A, Schulz AM, Galanopoulos A, Agar A, Healey PR, Hewitt AW, Graham SL, Landers J, Casson RJ, Siggs OM, Craig JE. Qassim A, et al. Among authors: agar a. Ophthalmology. 2021 Jul;128(7):993-1004. doi: 10.1016/j.ophtha.2020.11.021. Epub 2020 Nov 25. Ophthalmology. 2021. PMID: 33245936
A Polygenic Risk Score Predicts Intraocular Pressure Readings Outside Office Hours and Early Morning Spikes as Measured by Home Tonometry.
Qassim A, Mullany S, Awadalla MS, Hassall MM, Nguyen T, Marshall H, Kolovos A, Schulz AM, Han X, Gharahkhani P, Galanopoulos A, Agar A, Healey PR, Hewitt AW, Landers J, Casson RJ, Graham SL, MacGregor S, Souzeau E, Siggs OM, Craig JE. Qassim A, et al. Among authors: agar a. Ophthalmol Glaucoma. 2021 Jul-Aug;4(4):411-420. doi: 10.1016/j.ogla.2020.12.002. Epub 2020 Dec 11. Ophthalmol Glaucoma. 2021. PMID: 33316431
235 results