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Year Number of Results
1980 1
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1989 2
1990 3
1991 2
1992 3
1994 3
1995 3
1997 5
1998 4
1999 3
2000 3
2001 5
2002 2
2003 4
2004 9
2005 8
2006 4
2007 13
2008 16
2009 17
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476 results

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Page 1
Taurine Activates SIRT1/AMPK/FOXO1 Signaling Pathways to Favorably Regulate Lipid Metabolism in C57BL6 Obese Mice.
Karikkakkavil Prakashan AD, Muthukumar SP, Martin A. Karikkakkavil Prakashan AD, et al. Mol Nutr Food Res. 2024 Apr;68(8):e2200660. doi: 10.1002/mnfr.202200660. Epub 2024 Mar 29. Mol Nutr Food Res. 2024. PMID: 38549461
This study is conducted to evaluate the lipid lowering effect of dietary taurine administration on high-fat fed C57BL6 mice and to study the mechanism by which taurine impacts lipid metabolism. METHODS AND RESULTS: C57BL6 mice are grouped into four (n = 6): i) normal diet …
This study is conducted to evaluate the lipid lowering effect of dietary taurine administration on high-fat fed C57BL6 mice and to st …
Metabolomics-Based Effects of a Natural Product on Remyelination After Cerebral Ischemia Injury Via GABABR-pCREB-BDNF Pathway.
Fan X, Zhan M, Song W, Yao M, Wang G, Li T, Zhang Y, Liu J. Fan X, et al. Neurorehabil Neural Repair. 2024 May;38(5):350-363. doi: 10.1177/15459683241238733. Epub 2024 Mar 16. Neurorehabil Neural Repair. 2024. PMID: 38491852
BACKGROUND: Yi-Qi-Tong-Luo Granules (YQTLs) is a natural compound of Traditional Chinese Medicine authorized by China Food and Drug Administration (CFDA). These granules are employed in the convalescent stage of cerebral infarction and render notable clinical …
BACKGROUND: Yi-Qi-Tong-Luo Granules (YQTLs) is a natural compound of Traditional Chinese Medicine authorized by China Food and Dru …
Impact of sunitinib resistance on clear cell renal cell carcinoma therapeutic sensitivity in vitro.
Ghosh S, Garige M, Haggerty PR, Norris A, Chou CK, Wu WW, Shen RF, Sourbier C. Ghosh S, et al. Cell Cycle. 2024 Jan;23(1):43-55. doi: 10.1080/15384101.2024.2306760. Epub 2024 Jan 23. Cell Cycle. 2024. PMID: 38263737 Free PMC article.
We sought to characterize the molecular and metabolic changes induced by the development of sunitinib resistance in ccRCC by developing and characterizing two human ccRCC cell lines resistant to sunitinib. Consistent with the literature, sunitinib-resistant ccRCC cell line …
We sought to characterize the molecular and metabolic changes induced by the development of sunitinib resistance in ccRCC by developing and …
Prevalence and Molecular Characterization of Shiga Toxin-Producing Escherichia coli from Food and Clinical Samples.
Alotaibi K, Khan AA. Alotaibi K, et al. Pathogens. 2023 Oct 31;12(11):1302. doi: 10.3390/pathogens12111302. Pathogens. 2023. PMID: 38003767 Free PMC article.
The clinical samples were found to be resistant to Nb (100%), Tet (100%), Amp (20%), SXT (15%), and Kan (15%) antibiotics. In contrast, the food strains were found to be resistant to Nb (100%), Tet (33%), Amp (16.6%), and SXT (16.6%) antibiotics. ...Therefore …
The clinical samples were found to be resistant to Nb (100%), Tet (100%), Amp (20%), SXT (15%), and Kan (15%) antibiotics. In contras …
Morphologically-Directed Raman Spectroscopy as an Analytical Method for Subvisible Particle Characterization in Therapeutic Protein Product Quality.
Kim M, Ma Y, Srinivasan C, O'Connor T, Telikepalli SN, Ripple DC, Lute S, Bhirde A. Kim M, et al. Sci Rep. 2023 Nov 22;13(1):20473. doi: 10.1038/s41598-023-45720-0. Sci Rep. 2023. PMID: 37993487 Free PMC article.
Subvisible particles (SVPs) are a critical quality attribute of injectable therapeutic proteins (TPs) that needs to be controlled due to potential risks associated with drug product quality. The current compendial methods routinely used to analyze SVPs for lot release prov …
Subvisible particles (SVPs) are a critical quality attribute of injectable therapeutic proteins (TPs) that needs to be controlled due to pot …
A human lung alveolus-on-a-chip model of acute radiation-induced lung injury.
Dasgupta Q, Jiang A, Wen AM, Mannix RJ, Man Y, Hall S, Javorsky E, Ingber DE. Dasgupta Q, et al. Nat Commun. 2023 Oct 16;14(1):6506. doi: 10.1038/s41467-023-42171-z. Nat Commun. 2023. PMID: 37845224 Free PMC article.
The radiation dose sensitivity observed on-chip is more like the human lung than animal preclinical models. The Alveolus Chip is also used to evaluate the potential ability of two drugs - lovastatin and prednisolone - to suppress the effects of acute RILI. These data demon …
The radiation dose sensitivity observed on-chip is more like the human lung than animal preclinical models. The Alveolus Chip is also …
Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics.
Ouyang W, Xie T, Fang H, Frucht DM. Ouyang W, et al. Toxins (Basel). 2023 Aug 28;15(9):528. doi: 10.3390/toxins15090528. Toxins (Basel). 2023. PMID: 37755954 Free PMC article.
For this reason, anti-PA antibodies have been developed as therapeutics for prophylaxis and treatment of human anthrax infection. Assays described publicly for the control of anti-PA antibody potency quantify inhibition of LT-mediated cell death or the ET-induced increase …
For this reason, anti-PA antibodies have been developed as therapeutics for prophylaxis and treatment of human anthrax infection. Ass …
Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas.
Yin J, Wang X, Ge X, Ding F, Shi Z, Ge Z, Huang G, Zhao N, Chen D, Zhang J, Agnihotri S, Cao Y, Ji J, Lin F, Wang Q, Zhou Q, Wang X, You Y, Lu Z, Qian X. Yin J, et al. Nat Commun. 2023 Sep 22;14(1):5913. doi: 10.1038/s41467-023-41663-2. Nat Commun. 2023. PMID: 37737247 Free PMC article.
This conversion is catalyzed by hypoxanthine phosphoribosyl transferase 1 (HPRT1), which is highly expressed in human GBMs. As the bona fide activator of AMP-activated protein kinase (AMPK), TMZ-derived AICAR activates AMPK to phosphorylate threonine 52 (T52) of RRM …
This conversion is catalyzed by hypoxanthine phosphoribosyl transferase 1 (HPRT1), which is highly expressed in human GBMs. As the bo …
Cabernet sauvignon dry red wine ameliorates atherosclerosis in mice by regulating inflammation and endothelial function, activating AMPK phosphorylation, and modulating gut microbiota.
Cheng X, Han X, Zhou L, Sun Y, Zhou Q, Lin X, Gao Z, Wang J, Zhao W. Cheng X, et al. Food Res Int. 2023 Jul;169:112942. doi: 10.1016/j.foodres.2023.112942. Epub 2023 May 4. Food Res Int. 2023. PMID: 37254366
Here, we examined the anti-atherosclerotic effect of Cabernet Sauvignon DRW (CSDRW) in a mouse model of atherosclerosis (AS) using metabolomic profiling and molecular techniques. Oral administration of CSDRW reduced atherosclerotic lesion size in ApoE(-/-) mice, alleviated …
Here, we examined the anti-atherosclerotic effect of Cabernet Sauvignon DRW (CSDRW) in a mouse model of atherosclerosis (AS) using metabolom …
Quantitative tandem mass spectrometry in the clinical laboratory: Regulation and opportunity for validation of laboratory developed tests.
Stone JA, van der Gugten JG. Stone JA, et al. J Mass Spectrom Adv Clin Lab. 2023 Mar 5;28:82-90. doi: 10.1016/j.jmsacl.2023.03.001. eCollection 2023 Apr. J Mass Spectrom Adv Clin Lab. 2023. PMID: 36937811 Free PMC article. Review.
Tandem mass spectrometry is an important analytical tool for clinical laboratories, but tests developed and validated in-house (laboratory developed tests, or LDTs) require special consideration. In late 2022, the forecast for United States (U.S.) federal regulation …
Tandem mass spectrometry is an important analytical tool for clinical laboratories, but tests developed and validated in-house (laboratory d …
476 results