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Identification of potent and selective amidobipyridyl inhibitors of protein kinase D.
Meredith EL, Beattie K, Burgis R, Capparelli M, Chapo J, Dipietro L, Gamber G, Enyedy I, Hood DB, Hosagrahara V, Jewell C, Koch KA, Lee W, Lemon DD, McKinsey TA, Miranda K, Pagratis N, Phan D, Plato C, Rao C, Rozhitskaya O, Soldermann N, Springer C, van Eis M, Vega RB, Yan W, Zhu Q, Monovich LG. Meredith EL, et al. Among authors: jewell c. J Med Chem. 2010 Aug 12;53(15):5422-38. doi: 10.1021/jm100076w. J Med Chem. 2010. PMID: 20684592
Identification of orally available naphthyridine protein kinase D inhibitors.
Meredith EL, Ardayfio O, Beattie K, Dobler MR, Enyedy I, Gaul C, Hosagrahara V, Jewell C, Koch K, Lee W, Lehmann H, McKinsey TA, Miranda K, Pagratis N, Pancost M, Patnaik A, Phan D, Plato C, Qian M, Rajaraman V, Rao C, Rozhitskaya O, Ruppen T, Shi J, Siska SJ, Springer C, van Eis M, Vega RB, von Matt A, Yang L, Yoon T, Zhang JH, Zhu N, Monovich LG. Meredith EL, et al. Among authors: jewell c. J Med Chem. 2010 Aug 12;53(15):5400-21. doi: 10.1021/jm100075z. J Med Chem. 2010. PMID: 20684591
(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides are orally active inhibitors of pyruvate dehydrogenase kinase.
Aicher TD, Anderson RC, Bebernitz GR, Coppola GM, Jewell CF, Knorr DC, Liu C, Sperbeck DM, Brand LJ, Strohschein RJ, Gao J, Vinluan CC, Shetty SS, Dragland C, Kaplan EL, DelGrande D, Islam A, Liu X, Lozito RJ, Maniara WM, Walter RE, Mann WR. Aicher TD, et al. Among authors: jewell cf. J Med Chem. 1999 Jul 29;42(15):2741-6. doi: 10.1021/jm9902584. J Med Chem. 1999. PMID: 10425084 No abstract available.
Absorption and disposition of a tripeptoid and a tetrapeptide in the rat.
Wang Y, Lin H, Tullman R, Jewell CF Jr, Weetall ML, Tse FL. Wang Y, et al. Among authors: jewell cf jr. Biopharm Drug Dispos. 1999 Mar;20(2):69-75. doi: 10.1002/(sici)1099-081x(199903)20:2<69::aid-bdd153>3.0.co;2-b. Biopharm Drug Dispos. 1999. PMID: 10206321
The thiol methyltransferase activity of TMT1A (METTL7A) is conserved across species.
González Dalmasy JM, Fitzsimmons CM, Frye WJE, Perciaccante AJ, Jewell CP, Jenkins LM, Batista PJ, Robey RW, Gottesman MM. González Dalmasy JM, et al. Among authors: jewell cp. Chem Biol Interact. 2024 May 1;394:110989. doi: 10.1016/j.cbi.2024.110989. Epub 2024 Apr 3. Chem Biol Interact. 2024. PMID: 38574836
284 results