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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
1953 2
1954 3
1956 5
1957 4
1958 3
1959 3
1960 5
1961 1
1962 1
1963 2
1964 1
1967 2
1970 1
1971 3
1972 1
1974 2
1975 2
1976 7
1977 2
1978 4
1979 7
1980 12
1981 16
1982 19
1983 32
1984 38
1985 28
1986 26
1987 16
1988 15
1989 20
1990 13
1991 10
1992 6
1993 29
1994 24
1995 24
1996 25
1997 24
1998 19
1999 39
2000 36
2001 55
2002 71
2003 74
2004 89
2005 122
2006 118
2007 117
2008 130
2009 131
2010 170
2011 177
2012 168
2013 193
2014 188
2015 176
2016 158
2017 165
2018 175
2019 151
2020 156
2021 150
2022 166
2023 139
2024 43

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3,408 results

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Page 1
The Stanniocalcin-PAPP-A-IGFBP-IGF Axis.
Oxvig C, Conover CA. Oxvig C, et al. J Clin Endocrinol Metab. 2023 Jun 16;108(7):1624-1633. doi: 10.1210/clinem/dgad053. J Clin Endocrinol Metab. 2023. PMID: 36718521 Review.
The pappalysin metalloproteinases, PAPP-A and PAPP-A2, have emerged as highly specific proteolytic enzymes involved in the regulation of insulin-like growth factor (IGF) signaling. ...Stanniocalcin-1 and -2 were recently found to be potent pappalysin inhibitors, thu …
The pappalysin metalloproteinases, PAPP-A and PAPP-A2, have emerged as highly specific proteolytic enzymes involved in the reg …
PAPP-A and cancer.
Conover CA, Oxvig C. Conover CA, et al. J Mol Endocrinol. 2018 Jul;61(1):T1-T10. doi: 10.1530/JME-17-0236. J Mol Endocrinol. 2018. PMID: 29844094 Review.
In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and function, and post-translational inhibitors of PAPP-A expression or proteolytic activity. We will then …
In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP- …
The Pregnancy-Associated Plasma Protein-A (PAPP-A) Story.
Conover CA, Oxvig C. Conover CA, et al. Endocr Rev. 2023 Nov 9;44(6):1012-1028. doi: 10.1210/endrev/bnad017. Endocr Rev. 2023. PMID: 37267421 Review.
Pregnancy-associated plasma protein-A (PAPP-A) was first identified in the early 1970s as a placental protein of unknown function, present at high concentrations in the circulation of pregnant women. ...This proteolytic regulation …
Pregnancy-associated plasma protein-A (PAPP-A) was first identified in the early 1970s as a …
PAPP-A: a promising therapeutic target for healthy longevity.
Conover CA, Oxvig C. Conover CA, et al. Aging Cell. 2017 Apr;16(2):205-209. doi: 10.1111/acel.12564. Epub 2016 Dec 29. Aging Cell. 2017. PMID: 28035757 Free PMC article. Review.
Pregnancy-associated plasma protein-A (PAPP-A) is a proteolytic enzyme that was discovered to increase local insulin-like growth factor (IGF) availability for receptor activation through cleavage of inhibitory IGF binding proteins …
Pregnancy-associated plasma protein-A (PAPP-A) is a proteolytic enzyme that was discovered …
PAPP-A and the IGF system in atherosclerosis: what's up, what's down?
Steffensen LB, Conover CA, Oxvig C. Steffensen LB, et al. Am J Physiol Heart Circ Physiol. 2019 Nov 1;317(5):H1039-H1049. doi: 10.1152/ajpheart.00395.2019. Epub 2019 Sep 13. Am J Physiol Heart Circ Physiol. 2019. PMID: 31518159 Free PMC article. Review.
Pregnancy-associated plasma protein-A (PAPP-A) is a metalloproteinase with a well-established role in releasing bioactive insulin-like growth factor-1 (IGF-1) from IGF-binding protein-2, -4, and -5 by proteolytic processing of thes …
Pregnancy-associated plasma protein-A (PAPP-A) is a metalloproteinase with a well-establish …
PAPP-A and the IGF system.
Monget P, Oxvig C. Monget P, et al. Ann Endocrinol (Paris). 2016 Jun;77(2):90-6. doi: 10.1016/j.ando.2016.04.015. Epub 2016 May 5. Ann Endocrinol (Paris). 2016. PMID: 27155776 Review.
Firstly discovered as a placental protein present abundantly in the circulation of pregnant women, pregnancy-associated plasma protein-A (PAPP-A) is widely expressed in multiple tissues. ...By taking advantage of the intricate inte …
Firstly discovered as a placental protein present abundantly in the circulation of pregnant women, pregnancy-associated pla …
PAPP-A2 a new key regulator of growth.
Banaszak-Ziemska M, Niedziela M. Banaszak-Ziemska M, et al. Endokrynol Pol. 2017;68(6):682-691. doi: 10.5603/EP.a2017.0060. Endokrynol Pol. 2017. PMID: 29238946 Free article. Review.
Two proteases important for the proper functioning of the GH/IGF axis: pregnancy-associated plasma protein-A (PAPP-A) and pregnancy-associated plasma protein-A2 (PAPP-A2), have been described. ...
Two proteases important for the proper functioning of the GH/IGF axis: pregnancy-associated plasma protein-A …
First trimester serum PAPP-A is associated with placenta accreta: a retrospective study.
Wang F, Chen S, Wang J, Wang Y, Ruan F, Shu H, Zhu L, Man D. Wang F, et al. Arch Gynecol Obstet. 2021 Mar;303(3):645-652. doi: 10.1007/s00404-020-05960-1. Epub 2021 Jan 30. Arch Gynecol Obstet. 2021. PMID: 33515274 Review.
PURPOSE: Our objective of this study was to investigate whether first trimester serum pregnancy-associated plasma protein-A (PAPP-A) differed amongst pregnancies with placenta previa-accreta and non-adherent placenta previa and hea …
PURPOSE: Our objective of this study was to investigate whether first trimester serum pregnancy-associated plasma pr …
IGFBP-4 and PAPP-A in normal physiology and disease.
Hjortebjerg R. Hjortebjerg R. Growth Horm IGF Res. 2018 Aug;41:7-22. doi: 10.1016/j.ghir.2018.05.002. Epub 2018 May 30. Growth Horm IGF Res. 2018. PMID: 29864720 Review.
Insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) is a modulator of the IGF system, exerting both inhibitory and stimulatory effects on IGF-induced cellular growth. IGFBP-4 is the principal substrate for the enzyme pregnancy-associated plasma pr …
Insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) is a modulator of the IGF system, exerting both inhibitory and stimulatory effe …
Implications of the PAPP-A-IGFBP-IGF-1 pathway in the pathogenesis and treatment of polycystic kidney disease.
Kashyap S, Zeidler JD, Chini CCS, Chini EN. Kashyap S, et al. Cell Signal. 2020 Sep;73:109698. doi: 10.1016/j.cellsig.2020.109698. Epub 2020 Jun 20. Cell Signal. 2020. PMID: 32569826 Free PMC article. Review.
Recently, we demonstrated that caloric restriction can prevent the development of cystic disease in animal models of ADPKD and through these studies identified a new role for pregnancy associated plasma protein-A (PAPP-A), a compon …
Recently, we demonstrated that caloric restriction can prevent the development of cystic disease in animal models of ADPKD and through these …
3,408 results