Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia.
Leal-Lasarte MM, Franco JM, Labrador-Garrido A, Pozo D, Roodveldt C.
Leal-Lasarte MM, et al. Among authors: pozo d.
FASEB J. 2017 Jul;31(7):2797-2816. doi: 10.1096/fj.201601163R. Epub 2017 Mar 23.
FASEB J. 2017.
PMID: 28336525
Our study provides new insight into the immune phenotype, mechanisms, and signaling pathways that operate in microglial neurotoxic activation in ALS.-Leal-Lasarte, M. M., Franco, J. M., Labrador-Garrido, A., Pozo, D., Roodveldt, C. Extracellular TDP-43 aggregates ta …
Our study provides new insight into the immune phenotype, mechanisms, and signaling pathways that operate in microglial neurotoxic activatio …